Obesity Clinical Trial - Mitochondrial Methylation in Type 2 Diabetes

Status Completed

Clinical Trial Summary

The overarching goal of this proposal is to determine whether DNA methylation of the mitochondrial DNA impairs mitochondrial function in insulin resistant states such as overweight/obesity and type 2 diabetes.

Clinical Trial Description

To determine whether differences in human skeletal muscle DNA methylation patterns in the mitochondrial and nuclear genome can explain the lower abundance of ETC and OXPHOS mRNA and protein observed in insulin resistant skeletal muscle of overweight/obese and type 2 diabetic participants. To determine whether patterns of human skeletal muscle DNA methylation in the mitochondrial and nuclear genome are predictive of ETC function. We will isolate skeletal muscle mitochondria from metabolically well-characterized lean insulin sensitive, overweight/obese insulin resistant nondiabetic and obese insulin resistant type 2 diabetic volunteers, and functionally evaluate each ETC complex (I - IV) and complex V (ATP synthase). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04126551
Study type	Observational
Source	University of Arizona
Contact
Status	Completed
Phase
Start date	July 23, 2019
Completion date	December 31, 2023

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