Obesity Clinical Trial
Official title:
Alterations in Phosphorylated Fetuin-A, a Novel Regulator of Insulin Action in Insulin Resistance and Metabolic Syndrome: Effects of Lifestyle Modification
Verified date | March 2018 |
Source | Auburn University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Fetuin-A has been identified as a novel physiological regulator of insulin action in vitro, in intact cells and in vivo in animals. Previous research has shown that circulating levels of fetuin-A were increased in animal models of insulin resistance and diabetes. Additionally, several human investigation studies demonstrate a correlation of fetuin-A levels with body mass index, insulin resistance, and a fatty liver. Recently, the investigators have elucidated the role of fetuin-A phosphorylation in the regulation of insulin action, demonstrating that phosphorylation is critical for the inhibitory activity of fetuin-A. The objectives of this study are twofold: (1) Quantitate phosphorylated fetuin-A levels in individuals with insulin resistance and metabolic syndrome, and (2) Investigate the effects of lifestyle modifications (acute or chronic exercise and dietary modifications) on fetuin-A phosphorylation and insulin sensitivity.
Status | Completed |
Enrollment | 42 |
Est. completion date | May 31, 2015 |
Est. primary completion date | May 31, 2015 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 30 Years to 65 Years |
Eligibility |
Inclusion Criteria: - 30 to 65 years of age - obese (BMI > 30 kg·m2 or % fat > 30, and waist girth > 88 cm) - weight stable over the previous 6 months Exclusion Criteria: - smoker - documented cardiovascular or metabolic disease - currently taking medication to alter lipid or glucose metabolism - practicing regular leisure physical activity over the previous 6 months - engaged in strenuous vocational activity over the previous 6 months - signs or symptoms of latent heart disease - conditions that would preclude treadmill walking |
Country | Name | City | State |
---|---|---|---|
United States | Auburn University | Auburn | Alabama |
Lead Sponsor | Collaborator |
---|---|
Auburn University |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Total plasma fetuin-A and phosphorylated fetuin-A | Measure total fetuin-A and phosphorylated fetuin-A levels in plasma | Total fetuin-A and phosphorylated fetuin-A levels will be measured once every 4 weeks until participant achieves a targeted weight-loss goal of 8-10%. It is anticipated that most participants will achieve their weight-loss goal within 6-10 months. |
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