Obesity Clinical Trial
Official title:
Effect of Weight Loss on Lipids Concentration and Cholesterol Metabolism in Overweight and Obese Subjects With Primary Hypercholesterolemia.
Background: Lipid lowering response to weight loss in subjects with genetic hyperlipidemias
and overweight or obesity and its effect on cholesterol metabolism has not been studied.
Objective: To explore the effects of weight loss on lipid values and cholesterol metabolism,
by measuring circulating non-cholesterol sterols, in overweight or obese subjects with
genetic hypercholesterolemias.
Design: The investigators conducted a 6-months weight loss intervention in subjects with the
diagnosis of familial hypercholesterolemia (FH) or familial combined hyperlipidemia (FCHL),
body mass index >25 kg/m2, steady weight (±3 kg in the last 3 months) and absence of lipid
lowering drugs in the previous 5 weeks. They were advised to follow a hypocaloric diet with
a deficit of 600 kcal (30% fat, 15% protein, and 55% carbohydrates) per day as calculated
from the person's resting energy expenditure and activity level. Anthropometric data,
biochemical analysis including lipids, apolipoproteins and non-cholesterol sterols were
evaluated at baseline, 3 months and 6 months.
n/a
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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