Obesity Clinical Trial
Official title:
A Double-Blind Randomized Controlled Clinical Trial of Chromium Picolinate on Clinical and Biochemical Features of the Metabolic Syndrome
The purpose of this study is to determine whether chromium supplements can reduce symptoms of metabolic syndrome, a collection of symptoms that increase one's risk for developing heart disease, stroke, and diabetes.
Metabolic syndrome is a serious condition that may lead to a number of life-threatening
diseases. A reduction in the symptoms of metabolic syndrome could result in decreased
morbidity and health care costs and increased quality of life.
Chromium is an essential mineral that is used in the breakdown of fats, protein, and
carbohydrates. The cholesterol-lowering and blood sugar-stabilizing properties of chromium
make the supplement a strong candidate for reducing the symptoms of metabolic syndrome. This
study will determine whether chromium supplements can reduce symptoms of metabolic syndrome
in abdominally obese individuals.
Participants will be randomly assigned to receive either chromium supplements or placebo
daily for 16 weeks. Participants will have study visits at study start and at Months 2 and
4. A follow-up visit will occur 5 months after the end of the intervention period. Blood
tests, urine tests, and nail clippings will be used to assess lipoprotein cholesterol,
insulin response to glucose, lean body mass, blood pressure, oxidative stress, and chromium
levels in participants.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment
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