Obesity Clinical Trial
— SPROUTvsFATOfficial title:
Effects of the Consumption of Broccoli Sprouts in Overweight Subjects
Verified date | December 2017 |
Source | Universidad Católica San Antonio de Murcia |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Nowadays there is an increasing demand by consumers on healthy food products prepared in
convenient forms, simple to use and not containing additives. In this sense, broccoli sprouts
(Brassica oleraceae var. italica) represent an interesting choice as they are rich in
glucosinolates, nitrogen-sulfur compounds, that are believed to counteract the negative
effects of diverse pathologies.
Human studies have been focused on the antitumoral properties of these vegetables, however
there is less evidence on the anti-inflammatory properties of cruciferous vegetables in
humans.
As obesity is linked to an inflammatory component, the aim of the study is to evaluate the
anti-inflammatory action of broccoli sprouts in overweight adult subjects.
Status | Completed |
Enrollment | 40 |
Est. completion date | July 2017 |
Est. primary completion date | July 2016 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 35 Years to 55 Years |
Eligibility |
Inclusion Criteria: BMI within the overweight range according to the World Health Organization criteria (24.9-29.9 kg/m2), aged 35-55 years, taking no vitamins, supplements or medication during the previous two months; no-smoking. Exclusion Criteria: Diagnosed diseases as hypertension and cardiovascular pathologies, diabetes, hepatic, gastrointestinal and renal diseases, as well as the intake of drugs related to these pathologies, vegetarian diet, pregnancy or breastfeeding. |
Country | Name | City | State |
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n/a |
Lead Sponsor | Collaborator |
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Universidad Católica San Antonio de Murcia | Consejo Superior de Investigaciones Científicas (CSIC), Spain |
Baenas N, Suárez-Martínez C, García-Viguera C, Moreno DA. Bioavailability and new biomarkers of cruciferous sprouts consumption. Food Res Int. 2017 Oct;100(Pt 1):497-503. doi: 10.1016/j.foodres.2017.07.049. Epub 2017 Jul 21. — View Citation
Baenas N, Villaño D, García-Viguera C, Moreno DA. Optimizing elicitation and seed priming to enrich broccoli and radish sprouts in glucosinolates. Food Chem. 2016 Aug 1;204:314-9. doi: 10.1016/j.foodchem.2016.02.144. Epub 2016 Feb 26. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in IL-6 levels | Plasma levels of IL-6 measured at days 0, 70, 90 and 160 days of intervention | Changes observed from baseline at day 0 compared to 70, 90, 160 days | |
Primary | Change in C-reactive protein | Plasma levels of C-reactive protein measured at days 0, 70, 90 and 160 days of intervention | Changes observed from baseline at day 0 compared to 70, 90, 160 days | |
Secondary | Bioavailability of glucosinolates from broccoli sprouts | 24 h-urine levels of glucosinolates and their metabolites measured by UHPLC-MS/MS | Changes observed from baseline at day 0 compared to 70, 90, 160 days |
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