Association Between Low Dose Acetylsalicylic Acid (ASA) and Proton Pump Inhibitors and Risk of Acute Myocardial Infarction or Coronary Death

Nonfatal Myocardial Infarction Clinical Trial

Official title: Association Between Low Dose Acetylsalicylic Acid (ASA) and Proton Pump Inhibitors and Risk of Acute Myocardial Infarction or Coronary Heart Disease Death - Nested Case Control Analyses in a Cohort of First-time Users of Low Dose ASA for Secondary Prevention of Cerebrovascular and Cardiovascular Outcomes.

Status Completed

Clinical Trial Summary

The purpose of this study is to estimate the risk of myocardial infarction (MI)/coronary death associated with use of monotherapy low dose ASA (single antiplatelet) as well as concomitant use of monotherapy low dose ASA and proton pump inhibitors (PPIs) in first- time users of low dose ASA for secondary prevention using a UK primary care database.

Clinical Trial Description

Number of Anticipated Subjects: In case-control analysis 5.000-10.000 ;

Study Design

Observational Model: Cohort, Time Perspective: Retrospective

Related Conditions & MeSH terms

• Coronary Death
• Death
• Infarction
• Myocardial Infarction
• Nonfatal Myocardial Infarction

• NCT number: NCT01360047
• Study type: Observational
• Source: AstraZeneca
• Status: Completed
• Phase: N/A
• Start date: June 2011
• Completion date: December 2011