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NCT ID: NCT03845439 Recruiting - Time of Death Clinical Trials

Estimate of the TSD Based on the Quantification of the Tau Protein in CSF

Start date: November 1, 2017
Study type: Observational

Background: The accurate estimation of the time of death is a challenge in forensic medicine, as the methods routinely used to assess the post-mortem interval (PMI) are far from being precise. Recent developments in biochemical techniques may provide the opportunity to assist in more precise estimation of the time of death. The focus has been placed on the study of the biochemical profiles of closed compartment body fluids, as they are longer preserved than blood after death and subject to confined post-mortem chemical changes. Cerebrospinal fluid (CSF) has been considered as a suitable fluid to investigate these changes, as it is easy to sample and found in large amount. Due to its closeness to the central nervous system (CNS), CSF is used in clinical settings for the diagnosis of various CNS disorders such as Alzheimer's disease, whose diagnosis is mainly based on the increase of the concentrations of Tau protein and its phosphorylated isoform (p-Tau) in CSF. A post mortem leakage of Tau into the CSF has also been shown, reflecting progressive neuronal death as in Alzheimer's disease. In this exploratory, cross-sectional study, we investigated Tau in post mortem CSF as a potential biomarker of the time of death. Objectives: The main objective was to assess the correlation between the concentration of Tau in CSF and the PMI. The secondary objectives were (1) to determine the inter-individual variability of the concentration of Tau for a same PMI; (2) to determine the kinetics of this concentration over time in the same individual; (3) to determine the variability of this concentration according to the site of collection (lumbar vs. sub-occipital).

NCT ID: NCT03837574 Recruiting - Clinical trials for Congenital Heart Disease

French National Registry of Patients With Tetralogy of Fallot and Implantable Cardioverter Defibrillator

Start date: December 1, 2010
Study type: Observational [Patient Registry]

National french registry of patients with tetralogy of Fallot and implantable cardioverter defibrillator.

NCT ID: NCT03837522 Not yet recruiting - Kidney Transplant Clinical Trials

Trial to Define the Benefits and Harms of Deceased Donor Kidney Procurement Biopsies

Start date: April 2019
Phase: N/A
Study type: Interventional

The purpose of this research study is to compare the impact of the availability of biopsy results at the time of organ offers on the use and outcomes of kidneys from deceased donors.

NCT ID: NCT03833843 Recruiting - Clinical trials for Congenital Heart Disease

Sudden Cardiac in Systemic Right Ventricle

Start date: September 1, 2018
Study type: Observational

In complete transposition of the great arteries (TGA) with previous atrial switch repair, and congenitally corrected transposition of the great arteries (ccTGA), the morphological right ventricle and its tricuspid valve continue to support the systemic circulation. This results in late complications including including sudden death. This retrospective multicentric study aims to evaluate the prevalence of SCD in a contemporary population of patients with a systemic RV and identify specific risk factors for SCD and hemodynamically significant ventricular arrhythmia This registry records demographics, clinical, imaging data, electrophysiological and laboratory of patients with a sRV and a transposition of the great arteries Primary end points are defined by sudden cardiac death, near-miss sudden death, as well as sustained VT requiring defibrillation.

NCT ID: NCT03801681 Recruiting - Heart Failure Clinical Trials

ARrhythmias in MYocarditis

Start date: November 1, 2018
Study type: Observational [Patient Registry]

Myocarditis promotes the occurrence of serious cardiac arrhythmias and conduction disorders which may lead to sudden cardiac death, the need for catheter ablation of arrhythmia or implantation of a cardioverter-defibrillator or pacemaker. The aim of the study is to fill the evidence gap regarding the type and burden of arrhythmias in patients with myocarditis and their correlation with clinical parameters, biomarkers and additional tests. During a multi-center observational study, patients will be subjected to prolonged ECG monitoring. As a result, a risk scale will be created that can facilitate the identification of patients with an increased risk of arrhythmia and further specifying recommendations for therapeutic management.

NCT ID: NCT03798990 Recruiting - Death Clinical Trials

Reduce Speed Limits From 90km/h to 80 km/h on French Roads: Impact on Mortality

Start date: January 2015
Study type: Observational

On the first July 2018, the French government lowered the maximum authorized speeds on two-way roads without a central separator from 90 km/h to 80 km/h. The network concerned represents approximately 400 000 km of roads outside the built-up area, accounting for 55% of road deaths. The objective of the measure is to reduce the number of deaths on the roads concerned by encouraging the reduction of the average speed practiced by drivers. The analysis deals with a comparison of the number of killed persons on the network concerned, before and after the reduction of the speed limits. The "before" period is 2015-2017. The "after" period is from July 2018 to June 2019. The data used are extracted from the national bodily injury accident file (BAAC). The police fills this file for each road accidents occurring on a road open to public traffic and causing at least one victim (i.e., one user requiring medical care and involving at least one vehicle).

NCT ID: NCT03784586 Active, not recruiting - Clinical trials for Sudden Cardiac Death

Sudden Cardiac Death Stratification in Myotonic Dystrophy Type 1 Patients

Start date: February 1, 2012
Study type: Observational

The aim of the study is to evaluate if the electrophysiological study (EPS) guided therapy, including the prophylactic implantation of implantable cardioverter defibrillator (ICD), in inducible patients, is able to improve survival in comparison with conventional therapy (CONV strategy) in Myotonic Dystrophy type 1 patients with conduction disorders.

NCT ID: NCT03775954 Recruiting - Clinical trials for Congenital Heart Disease

Fetal Electrophysiologic Abnormalities in High-Risk Pregnancies Associated With Fetal Demise

Start date: July 1, 2018
Study type: Observational

Each year world-wide, 2.5 million fetuses die unexpectedly in the last half of pregnancy, 25,000 in the United States, making fetal demise ten-times more common than Sudden Infant Death Syndrome. This study will apply a novel type of non-invasive monitoring, called fetal magnetocardiography (fMCG) used thus far to successfully evaluate fetal arrhythmias, in order to discover potential hidden electrophysiologic abnormalities that could lead to fetal demise in five high-risk pregnancy conditions associated with fetal demise.

NCT ID: NCT03770741 Not yet recruiting - Brain Injuries Clinical Trials

Safeguarding the Brain of Our Smallest Infants Phase III

Start date: April 15, 2019
Phase: N/A
Study type: Interventional

the SafeBoosC-III trial investigates the benefit and harms of treatment based on near-infrared spectroscopy monitoring compared with treatment as usual. The hypothesis is that treatment based on near-infrared spectroscopy monitoring for extremely preterm infants during the first 72 hours of life will result in a reduction in severe brain injury or death at 36 weeks postmenstrual age.

NCT ID: NCT03769740 Recruiting - Cardiac Arrest Clinical Trials

Cerebral Oximetry and NIRS in Cardiac Arrest Patients

Start date: May 1, 2009
Study type: Observational

This is an observational study to define the role and future applications of cerebral oximetry in cardiac arrest patients.