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Neoplasms clinical trials

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NCT ID: NCT05197972 Recruiting - Surgery Clinical Trials

Assessment of Cardiac Coherence Associated With Medical Hypnosis on Preoperative Anxiety in Oncological Surgery

COHEC2
Start date: April 21, 2022
Phase: N/A
Study type: Interventional

The investigator proposes to use the cardiac coherence technique (Cardiac Coherence) coupled with a hypnosis session to reduce pre-operative anxiety.

NCT ID: NCT05196360 Recruiting - Solid Tumor Clinical Trials

MAX-10181 in Patients With Advanced Solid Tumor

PD-L1
Start date: August 11, 2021
Phase: Phase 1
Study type: Interventional

This is a multi-center, open-label, single-arm, dose-escalation Phase I study to evaluate the safety and tolerability of MAX-10181 in patients with advanced solid tumor.

NCT ID: NCT05194982 Recruiting - Clinical trials for Locally Advanced or Metastatic Solid Tumor

A Study of BL-B01D1 in Patients With Locally Advanced or Metastatic Solid Tumor

Start date: November 29, 2021
Phase: Phase 1
Study type: Interventional

In phase Ia study, the safety and tolerability of BL-B01D1 in patients with locally advanced or metastatic solid tumor will be investigated to determine the dose-limiting toxicity (DLT), maximum tolerated dose (MTD) of BL-B01D1. In phase Ib study, the safety and tolerability of BL-B01D1 at the phase Ia recommended dose will be further investigated, and recommended phase II dose (RP2D) for phase II clinical studies will be determined. In addition, the preliminary efficacy, pharmacokinetic characteristics, and immunogenicity of BL-B01D1 in patients with locally advanced or metastatic solid tumor will be evaluated.

NCT ID: NCT05194709 Recruiting - Clinical trials for Advanced Solid Tumors

Study of Anti-5T4 CAR-NK Cell Therapy in Advanced Solid Tumors

Start date: December 30, 2021
Phase: Early Phase 1
Study type: Interventional

This study is an interventional, single arm, open-label, investigator-initiated trial (IIT) to evaluate the safety, tolerability, initial efficacy and pharmacokinetics (PK) of anti-5T4 CAR-NK cells in patients with advanced solid tumors.

NCT ID: NCT05194072 Recruiting - Clinical trials for Carcinoma, Non-Small-Cell Lung

A Study of SGN-B7H4V in Advanced Solid Tumors

Start date: January 12, 2022
Phase: Phase 1
Study type: Interventional

This study will test the safety of a drug called SGN-B7H4V in participants with solid tumors. It will also study the side effects of this drug. A side effect is anything a drug does to the body besides treating the disease. Participants will have cancer that has spread in the body near where it started (locally advanced) and cannot be removed (unresectable) or has spread through the body (metastatic). This study will have three parts. Parts A and B of the study will find out how much SGN-B7H4V should be given to participants. Part C will use the dose found in Parts A and B to find out how safe SGN-B7H4V is and if it works to treat solid tumor cancers.

NCT ID: NCT05193721 Active, not recruiting - Clinical trials for Advanced Malignant Tumors

A Clinical Study of the Safety and Tolerability of SHR-1901 in Subjects With Advanced Malignant Tumors

Start date: February 10, 2022
Phase: Phase 1
Study type: Interventional

The study is being conducted to evaluate the efficacy, and safety of SHR-1901 in subjects with advanced malignant tumors.To explore the reasonable dosage of SHR-1901.

NCT ID: NCT05193292 Not yet recruiting - Clinical trials for Colorectal Neoplasms

Camrelizumab Combined With Trastuzumab and Chemotherapy in Patients With HER2-positive Advanced Colorectal Cancer

Start date: January 2022
Phase: Phase 2
Study type: Interventional

This study aimed to evaluate the efficacy and safety of camrelizumab combined with trastuzumab and chemotherapy in Patients with HER2-positive advanced colorectal cancer

NCT ID: NCT05192512 Recruiting - Advanced Cancer Clinical Trials

Clinical Trial of the TQB2928 Injection in Patients With Advanced Cancers

Start date: January 24, 2022
Phase: Phase 1
Study type: Interventional

TQB2928 is a promising new molecular entity that mediates blockade of CD47 and SIRPα (Signal Regulatory Protein Alpha) and enhances the phagocytosis of cancer cells by macrophages. This is a study to evaluate the safety, tolerability and effectiveness of TQB2928 injection in subjects with advanced malignancies.

NCT ID: NCT05192174 Recruiting - Solid Tumor Clinical Trials

Study of NIB101 in Participants With Advanced Solid Tumors

Start date: January 24, 2022
Phase: Phase 1
Study type: Interventional

NIB101-01 study is an open-label, non-randomized Phase 1 study in participants with GM2 positive advanced solid tumor, who failed to available standard of cares to evaluate the safety and tolerability of NIB101.

NCT ID: NCT05191641 Recruiting - Oncology Clinical Trials

Effect of Individualized Nursing Care for Parents of Pediatric Oncology Patients

Start date: July 20, 2023
Phase: N/A
Study type: Interventional

Objective: This study was planned to evaluate the effectiveness of individualized nursing care based on the Professional Values Model for parents of pediatric oncology patients. Method: Simple randomization will be used to evaluate the intervention and control groups. The sample of the study will be the parents of children aged 1-18 years (Intervention group: 35 parents, Control group: 35 parents) diagnosed with cancer in the Akdeniz University Hospital Pediatrics, Hematology and Oncology clinic and hospitalized. Portrait Values Questionnaire and PedsQL Health Care Satisfaction Hematology/Oncology Module Parent Form will be used to collect data. A 12-week individualized nursing care based on the Professional Values Model will be applied to 35 parents in the intervention group. The effectiveness of the program will be evaluated after all post-test applications are completed.