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Neoplasms clinical trials

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NCT ID: NCT06376604 Recruiting - Chemotherapy Effect Clinical Trials

Fasting Mimicking Diet in Chemotherapy of Gynecologic Malignancies

Start date: September 8, 2021
Phase: N/A
Study type: Interventional

This study evaluates how lifestyle modifications that may be made to manage chemotherapy side effects in patients with gynecologic malignancies.

NCT ID: NCT06375564 Recruiting - Clinical trials for Refractory Solid Tumor

Clinical Evaluation of 177Lu-AB-3PRGD2 in Various Solid Tumors With Integrin αvβ3 Positive Expression

Start date: May 1, 2024
Phase: Phase 1
Study type: Interventional

This is an open-label, non-controlled, non-randomized study to assess the therapeutic efficacy of 177Lu-AB-3PRGD2 in patients with various solid tumors who will undergo radioligand therapy using 177Lu-AB-3PRGD.

NCT ID: NCT06375161 Recruiting - B Cell Malignancies Clinical Trials

Anti-CD19-CAR-T Cells in Relapsed/Refractory B-cell Tumor Patients.

Start date: December 11, 2023
Phase: Early Phase 1
Study type: Interventional

This study is a single-center, open-label, single-dose clinical trial of anti-CD19-CAR-T cell therapy in relapsed/refractory B-cell tumor patients after Qinglin pre-treatment. In this study phase, a traditional "3+3" trial design is employed for dose escalation.

NCT ID: NCT06374173 Recruiting - Clinical trials for Advanced or Metastatic Solid Tumors

A Phase 1 Study to Evaluate TGI-6 in Subjects With Locally Advanced/Metastatic Solid Tumors

Start date: January 3, 2024
Phase: Phase 1
Study type: Interventional

A Phase 1 Study to Evaluate TGI-6 in Subjects with Locally Advanced/Metastatic Solid Tumors

NCT ID: NCT06373406 Recruiting - Clinical trials for Advanced Solid Tumor

A Phase I/II Study of MHB036C for Advanced Solid Tumor

Start date: May 18, 2023
Phase: Phase 1/Phase 2
Study type: Interventional

Phase I/II, dose escalation and dose expansion study to evaluate the efficacy and safety of MHB036C in advanced malignant tumors.

NCT ID: NCT06372236 Recruiting - Clinical trials for Conditions or Focus of Study: B7-H3 Positive Relapsed/Advanced Malignant Solid Tumor

UTAA06 Injection for Treatment of Advanced Malignant Solid Tumors

Start date: December 1, 2023
Phase: Phase 1
Study type: Interventional

This is a single-arm, open, early-stage clinical study. The main purpose of this study is to explore the maximum tolerated dose (MTD), the optimal phase II recommended dose, safety, initial anti-tumor activity, cytopharmacokinetics, immunogenicity, biomarkers and other characteristics of drug therapy in patients with advanced malignant solid tumors. Eligible subjects were transfused with UTAA06 injection after pretreatment, and their blood was collected before and after infusion for evaluation of cytopharmacokinetics, safety, immunogenicity and biomarkers. In this study, tumor evaluation was mainly performed using RECISTv1.1. In addition to the baseline period, the therapeutic efficacy was evaluated at the frequency of Q3m during 4w, 2m, 3m, and 6-24m after cell infusion. Tumor evaluation was performed until disease progression (PD), new anti-tumor therapy, death, intolerable toxicity, investigator's decision, or patient's voluntary withdrawal. Whichever comes first.

NCT ID: NCT06368960 Recruiting - Clinical trials for Advanced Solid Tumors

BM201 in Combination With Radiotherapy in Patients With Advanced Solid Tumors

BM201-1001
Start date: November 7, 2022
Phase: Phase 1
Study type: Interventional

This is a non-randomized,open-label,controlled multi-center Phase Ⅰ study to evaluate tolerability, pharmacokinetics, and preliminary efficacy of BM201 injection in combination with radiotherapy in patients with histologically or cytologically confirmed unresectable locally advanced or metastatic solid tumors who have failed standard therapy or are unable to receive standard treatment.

NCT ID: NCT06368921 Recruiting - Solid Tumor Clinical Trials

A Study of Recombinant Oncolytic Virus M1(VRT106) in Patients With Solid Tumors

Start date: April 2024
Phase: Phase 1
Study type: Interventional

To Evaluate the safety and tolerability of single and multiple intratumoral injections of recombinant oncolytic virus M1 (VRT106) in patients with locally advanced/metastatic solid tumors.

NCT ID: NCT06368661 Recruiting - Clinical trials for Nutrition Related Neoplasm/Cancer

Dietary Factors Associated to Colorectal Premalignant Lesions (COLOMAR-1)

Start date: September 1, 2023
Phase:
Study type: Observational

This study aims to find a correlation between fish protein intake and other dietary habits and colorectal premalignant lesions in healthy volunteers. It also aims to describe gut microbial profiles for each dietary pattern, in order to elucidate the role of fish intake in cancer prevention.

NCT ID: NCT06365866 Recruiting - Neoplasms Clinical Trials

Evaluate the Efficacy of Adding Intraluminal Brachytherapy After CCRT for Local-regional Thoracic Esophageal Cancer.

Start date: February 19, 2024
Phase: N/A
Study type: Interventional

The purpose of this study is to observe the safety and effectiveness of the add-on of intraluminal brachytherapy with BRAXX esophageal brachytherapy applicator after definitive CCRT in patients with thoracic esophageal cancer.