View clinical trials related to Musculoskeletal Diseases.
Filter by:The purpose of the ACCELERATE3 trial is to assess the efficacy of a single intra-articular (IA) injection of autologous BMAC, in one or both knees, compared to a single IA injection of Standard of Care (SOC) in patients with mild to severe knee OA.
Preclinical data indicate that very low carbohydrate ketogenic diets (KD) may prevent progression of age-related sarcopenia (skeletal muscle decline) but also may disturb bone metabolism. The investigators will pilot test a randomized trial comparing the effects of short-term adaptation to a well-formulated ketogenic diet and Mediterranean diet on markers of bone metabolism and muscle function in older adults. The expected results will help inform the benefit-risk assessment for older patients considering longer term use of KD therapy.
Musculoskeletal disorders (MSDs) of the limbs and spine are painful conditions of the periarticular soft tissues (muscles, tendons, vessels, etc.) and peripheral nerves secondary to overuse of occupational origin. They can manifest as pain (the most common symptom), discomfort, stiffness, loss of precision in movements or loss of strength. The lumbar spine and upper limbs are the parts of the body most frequently affected by MSDs. MSDs have a multifactorial origin that can be separated into 2 categories: factors linked to the individual (age, sex, medical history) and factors linked to the work environment (biomechanical constraints, work organization, psychosocial risks). MSDs are the leading cause of compensated occupational illnesses in France (86% of occupational illnesses in 2021, according to the Health Insurance annual report), particularly in the agricultural sector to which the majority of professions in green spaces belong. . If, in the Grand Est of France, the prevalence of employees exposed to physical risks decreased in the majority of sectors of activity between 1994 and 2017, we note at the same time a slight increase in the prevalence in the agricultural sector over this period. same period (6% in 2017 compared to 3.7% in 1994, SUMER 2017 survey). Concerning the current context in France, the green spaces sector has undergone changes in recent years following the national implementation of the Ecophyto plan in 2008 (updated in 2015 then in 2018). This plan, the latest version of which is called Ecophyto 2+, aims to reduce the use of plant protection products by 50% by 2025. At the same time, the use of plant protection products for the maintenance of green spaces, forests, roads and walks have been prohibited by the Labbé law since January 1, 2017. In this context, and given the absence of recent data from the literature on this subject in France, the investigator wishes to carry out an inventory recent physical and organizational constraints, as well as the prevalence of MSDs, in the green space sector (targeting more particularly in its study the green spaces of the Territorial Civil Service of the Grand Est)
1. Sample size will be 400. 2. Age starts from 24 years old and more. 3. Body mass index ( BMI ) between 18.5 to 24.9 kg/m2 4. Years of ordination - (1-3) years novice or probationary - (4-10) years of monasticism. - more than 10 years of monasticism. 5. Samples will be selected from several monasteries in Egypt. 6. All data collected by Arabic version of Nordic questionnaire.
Accidental falls in older adults are one of the world's major pubic health problem, because of their strong association with injuries and mortality rates. In Quebec, falls are responsible for a high rate of hospitalization (more than 1800 emergency department visits every day) and deaths (more than 10,000 in recent years). Preventing falls is therefore a key mission for health professionals. This research program aims to develop a new clinical approach to the rehabilitation management of the older with a neuro-musculoskeletal disorder and a risk of falling. This program is part of a new partnership project between UQAC and specialized geriatric services at the CIUSSS Saguenay-Lac-St-Jean (La Baie site). These geriatric services admit more than 400 new patients per year, representing a large pool of participants for the new program's development. Specifically, this program has 4 phases: 1) Create a clinical profile of patients in rehabilitation care from specialized geriatric services (ex: reasons for consultation, neuro-musculoskeletal disorders, rates and causes of falls, etc.); 2) to diagnose functional deficits of these patients on different dimensions of functional and physical evaluations, using standardized tests and high-tech instruments (ex: platform of force); 3) determine the effectiveness of a new exercise intervention program (OTAGO) for falls prevention; and 4) Measure client and professional team satisfaction as well as long-term impact of this new approach used to prevent falls. The most significant impact of this new program will be to reduce public health expenditure for care of older adults with balance disorder and risk for falls; and therefore, be implanted in other CIUSSS institutions from Quebec.
Primary care physiotherapy services provide community-based care for musculoskeletal conditions. These conditions are often associated with disability and impact on patients' quality of life. The International Classification of Functioning, Disability and Health (ICF) is the global framework for describing disability. ICF Core Sets are ICF-based tools that facilitate the clinical use of this classification. The development of these tools follows a scientific process that combines the perspectives of researchers, patients, professionals, and the care setting. Our research team has conducted preliminary studies and identified candidate ICF categories with good potential for inclusion in a preliminary version of an ICF Core Set for the treatment of musculoskeletal conditions in community physical therapy settings. The aim of this study is to confirm the relevance of the candidate categories and to develop a final version of this ICF Core Set.
The goal of this prospective observational study is to investigate the impact of tourniquet application on cardiac efficiency through the cardiac cycle efficiency parameter and to explore how central regional technique alters this effect compared to general anesthesia. We aim to answer the following main questions: 1) Does the use of a tourniquet reduce cardiac efficiency? 2) Does the impact of tourniquet use on cardiac efficiency vary with general anesthesia or central regional technique? The patients included in the study will be divided into two groups based on whether they receive general anesthesia or combined spinal epidural anesthesia.The patients' cardiac cycle efficiency and advanced hemodynamic monitoring parameters will be recorded during procedure.
The goal of this pilot study is to evaluate the feasibility of integrating neural mobilization techniques into a multimodal physical exercise program for older adults with chronic musculoskeletal pain. The main questions it aims to answer are: - What is the average time to assess secondary outcomes for each participant? - What proportion of participants adhered and/or withdrew from the study at the end of the intervention protocol? - Are there adverse events/effects associated with the intervention protocol? - What is the level of approval/satisfaction of the participants in relation to the assessment and intervention protocols? - What is the impact of the intervention protocol on participants´ pain, function, physical performance, somatosensory function, and nerve excursion (secondary outcomes)? Participants will be assessed at 3 different moments: initial assessment (T0), at the end of the intervention protocol (8 weeks) (T1) and 3 months after the end of the intervention protocol (T2). The intervention protocol will consist of a multimodal exercise program (with or without integration of neural mobilization techniques) to be carried out over a period of 8 weeks at a frequency of twice a week.
To examine the effect of education and consultancy provided via telenursing service after total knee arthroplasty on postoperative quality of life and some complications.
This is a prospective, single-center, observational clinical trial at the Department of Women's Health of the University Hospital Tübingen.