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Memory Deficits clinical trials

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NCT ID: NCT05569902 Completed - Memory Deficits Clinical Trials

tACS Improves Memory in Elders With Subjective Memory Complaints

Start date: October 1, 2021
Phase: N/A
Study type: Interventional

Subjective memory complaints (SMC), the main cognitive component of which is event memory, is a predictor of Alzheimer's disease in elderly people. The purpose of this study was to investigate the effect of transcranial alternating current stimulation (tACS) with theta frequency (6 Hz) on the medial prefrontal cortex in the improvement of episodic memory in individuals with SMC in a double blind, randomized, and sham-controlled parallel study. Sixteen participants with SMC received either active or sham theta tACS on the medial prefrontal cortex (mPFC). EEG was recorded and Rey Auditory Verbal Learning Test (RAVLT) was administered. The aim of the current study was to see if theta tACS over the mPFC can improve event memory in individuals with SMC and thus can be considered a potential therapeutic intervention for this population or not.

NCT ID: NCT05523115 Completed - Anxiety Clinical Trials

An Exploratory Investigation of a Supplement to Promote Cognitive Health Benefits

Start date: June 15, 2022
Phase: N/A
Study type: Interventional

The Smart Supplement has 20 vitamins and minerals that have strong track records of demonstrating positive health effects, both physiologically and cognitively. This twelve-week trial will examine the effectiveness and efficacy of Heights Smart Supplement on both biomarkers and subjective experiences from participants.

NCT ID: NCT05520424 Completed - Stress Clinical Trials

An Exploratory Investigation of a Supplement to Promote Brain Health

Start date: June 15, 2022
Phase: N/A
Study type: Interventional

Providing a combination of synergistic dietary supplements, such as vitamins B6, B12, and folate, as well as curcumin, lemon balm, and American ginseng is hypothesized to promote brain health and aid with brain fog, mental clarity, ability to handle stress, mood, focus, and productivity, as well as promote overall well-being.

NCT ID: NCT05170464 Completed - Memory Deficits Clinical Trials

The Acute Effects of Exercise and Caffeine on Working Memory During Acute Caffeine Deprivation

Start date: January 10, 2022
Phase: Phase 2/Phase 3
Study type: Interventional

To determine the effects of moderate intensity exercise and caffeine on working memory in deprived caffeine consumers.

NCT ID: NCT05051501 Completed - Aging Clinical Trials

The Effects of Microbiological Spectrum Changes to Improve Cognitive Health in Aging Population

CleverAgeBiota
Start date: January 6, 2021
Phase: Phase 2
Study type: Interventional

The goal of this project is to develop probiotic dietary supplements intended for the elderly, which can modify the composition of the intestinal microbiota typically occurring in the aging population. According to currently held scientific knowledge, it is postulated that the probiotics-induced normalization of the physiological axis in the brain-intestinal microbiota affects the activity of the nervous system. Thus, normalization of this axis should lead to observable improvements in cognitive functions and quality of life.

NCT ID: NCT03872310 Completed - Schizophrenia Clinical Trials

Cognitive Enhancement on Working Memory in Patients With Schizophrenia

CEWMPS
Start date: May 1, 2019
Phase: N/A
Study type: Interventional

The investigators plan to investigate the effect of enhancement on working memory (WM) in patients of chronic schizophrenia and determine the predictive factors of effective treatment.

NCT ID: NCT03812744 Completed - Memory Deficits Clinical Trials

Neurophysiological Effects of Whole Coffee Cherry Extract in Older Adults

Start date: October 1, 2016
Phase: N/A
Study type: Interventional

This study was designed to characterize the changes in the brain and body associated with whole coffee cherry extract (WCCE). WCCE is a patented extract of whole coffee fruit (coffee berries) from coffea arabica. Whole coffee cherries are a source of naturally occurring nutrients. There are no known side effects or allergens associated with WCCE other than that which would be associated with a consuming typical cup of coffee. Previous studies suggest that increases in serum concentrations of both serum total and exosomal brain-derived neurotrophic factors (BDNF) may represent one of the mechanisms responsible for improved cognitive function after acute WCCE administration. Mild cognitive impairment (MCI) is an intermediate stage between the expected cognitive decline of normal aging and the more serious decline of dementia. It can involve problems with memory, language, thinking and judgment that are greater than normal age-related changes. Furthermore, MCI is associated with reduced circulating BDNF. Due to earlier studies reporting the ability of WCCE to stimulate increases in circulating and exosomal BDNF, it has been postulated that WCCE may also acutely improve cognitive function (as measured using behavioral tasks and fMRI). The purpose of this study is to extend and elucidate the findings of previous investigations by examining the acute neurophysiological effects of WCCE using blood-oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) and magnetic resonance spectroscopy (MRS) employing a double-blind, randomized crossover design to investigate the acute effects of a single dose of WCCE or placebo (silica oxide) on neuronal activity in older participants.

NCT ID: NCT03727737 Completed - Aging Clinical Trials

Efficacy of Repetitive Transcranial Magnetic Stimulation for Improvement of Memory in Older Adults With TBI

Start date: October 23, 2018
Phase: N/A
Study type: Interventional

The proposed study will evaluate the safety, durability and efficacy of repetitive Transcranial Magnetic Stimulation (rTMS) as a promising non-invasive therapeutic treatment for improving memory in older adults with mild or moderate Traumatic Brain Injury (TBI) who have been experiencing residual memory or cognitive problems that affect daily functioning.

NCT ID: NCT02790151 Completed - Memory Deficits Clinical Trials

Memory Rehabilitation by Means of Working Memory Training in Combination With a Recollection Training

Start date: November 2014
Phase: N/A
Study type: Interventional

Memory deficits after brain damage are common and there is still a need for evaluated therapy methods. In this study we compare two therapeutic interventions and investigate whether therapy effects can be found on neuropsychological tests and on a test measuring memory in everyday life.

NCT ID: NCT02680210 Completed - Cognition Disorders Clinical Trials

Self-defining Memories in Patients With a TBI

IDENTITY
Start date: February 4, 2016
Phase: N/A
Study type: Interventional

The study will be conducted over 18 months. The main objective of this study is to explore the relationships between autobiographical memory and specific cognitive measures, as well as emotional and behavioural measures in patients who have suffered a moderate to severe TBI. Secondary objectives are to assess the psychometric properties of a self-defining memories questionnaire and to characterize autobiographical memory in the TBI population.