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Marijuana Abuse clinical trials

View clinical trials related to Marijuana Abuse.

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NCT ID: NCT05849636 Recruiting - Adolescent Behavior Clinical Trials

Alerta Cannabis: Evaluation of Web-based Tailored Intervention

NOTCANNABIS
Start date: October 1, 2022
Phase: N/A
Study type: Interventional

This study consists in the the design, implementation, and evaluation of the first web-based computer tailored intervention program aimed at the prevention of cannabis use in Spanish adolescents (ALERTA CANNABIS). A Cluster Randomized Controlled Trial is conducted to test the effectiveness of ALERTA CANNABIS in students aged 14 to 18 years across 34 high schools from Andalusia (southern Spain), which are randomized either to the experimental or the control condition (EC and CC).

NCT ID: NCT05836207 Recruiting - Clinical trials for Cannabis Use Disorder

Rewards for Cannabis Abstinence-study

RECAB
Start date: November 21, 2023
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to investigate the (cost-)effectiveness of contingency management (CM) compared with Cognitive Behavioural Therapy (CBT) for the treatment of cannabis use disorder (CUD) in youth (16-22 years). The main questions it aims to answer are: - What is the efficacy of 12 weeks outpatient CM versus CBT in youths with a CUD, in terms of cannabis abstinence during the intervention period? - What is the long-term efficacy of CM versus CBT at 6- and 12-months follow-up (FU)? - What is the cost-effectiveness of CM versus CBT at 12-months FU from a societal perspective? Study hypotheses are: 1. CM will result in more cannabis-abstinent days than CBT during the intervention; 2. CM is more effective and cost-effective than CBT at 12 months follow-up. Eligible patients (n=154) will be randomly assigned to either 12 weeks of outpatient CM or CBT. Assessments are conducted by trained research-assistants at baseline, after 6, 12, 26 and 52 weeks, and twice-weekly during treatment and consist of questionnaires, a computer task and collection of urine samples. Primary endpoint is the number of biochemically verified cannabis abstinent days in the 12-week treatment period. Key secondary endpoint: Treatment response: 50% or more reduction in cannabis use days in the past 4 weeks, compared with baseline. The primary outcome will be modelled in the intention-to-treat population in a (negative binomial) regression analysis with treatment group as independent variable and stratification variables as covariates. Cost-effectiveness and cost-utility analysis (CEA; CUA) will be performed from a societal perspective. CEA: Treatment response is the central clinical endpoint for calculations of incremental costs per responder. CUA: Incremental costs per QALY (based on EuroQoL).

NCT ID: NCT05833230 Recruiting - Cannabis Use Clinical Trials

Investigating Real-world Stress-related Mechanisms in Heavy Cannabis Users

CLR2
Start date: June 1, 2023
Phase: N/A
Study type: Interventional

This research project proposes a novel approach to elucidate the biological adaptations associated with heavy cannabis use and to assess whether such adaptations are predictive of higher cannabis craving in response to both cannabis cues and stressors.

NCT ID: NCT05814822 Recruiting - Insomnia Clinical Trials

Targeting Insomnia to Improve Outcomes in Adults With Problematic Cannabis Use

Start date: June 1, 2023
Phase: N/A
Study type: Interventional

This study will compare the efficacy of telemedicine-delivered cognitive behavioral therapy for insomnia tailored for people using cannabis for sleep (CBTi-CB-TM) to telemedicine-delivered sleep hygiene education (SHE-TM) on sleep, cannabis use, and daytime functioning. We will also evaluate the effects of CBTi-CB-TM on fundamental sleep regulatory system - homeostatic sleep drive - and its association with clinical outcomes.

NCT ID: NCT05765409 Recruiting - Clinical trials for Cannabis Use Disorder

Assessment of the Effectiveness of an Integrative Therapy for Cannabis Misuse in Adolescents

TIMCA
Start date: February 15, 2023
Phase: N/A
Study type: Interventional

The primary objective of this study is to evaluate an Integrative Therapy for Adolescent Cannabis Use (TIMCA), integrating elements of Motivational Interviewing (MI), Cognitive Behavioral Therapies (CBT) and an Attachment-Based Intervention (ABI), (IBA),compared to Treatment As Usual (TAU) on cannabis use. The secondary objectives of the study are: To assess the effectiveness of the TIMCA, in comparison to the TAU, on: (1) Relationship quality with parents, (2) Relationship quality with closest friend, (3) Emotional regulation strategies, (4) Depressive symptomatology, (5) Anxiety symptomatology, (6) Adherence to therapy

NCT ID: NCT05751369 Recruiting - Clinical trials for Knowledge, Attitudes, Practice

Addressing Tobacco, E-Cigarette, and Cannabis Waste

TECW
Start date: March 1, 2023
Phase: N/A
Study type: Interventional

This study tests of effect of brief education and support about tobacco, e-cigarette, and cannabis waste (TECW) on knowledge, beliefs, behavior, and TECW on two college campuses.

NCT ID: NCT05720312 Recruiting - Clinical trials for Cannabis Use Disorder

Investigating Two rTMS Strategies to Treat Cannabis Use Disorder

Start date: July 1, 2023
Phase: Phase 1/Phase 2
Study type: Interventional

In this trial we will work with a group of participants who are having problems related to marijuana use (they have Cannabis Use Disorder) and who want to reduce the amount of marijuana they use or quit using marijuana completely. We are testing to see if a treatment called repetitive transcranial magnetic stimulation (rTMS) can help them achieve that goal when combined with a brief three-session counseling therapy. Participants will receive rTMS to one of two different parts of the brain (the dorsolateral prefrontal cortex--the DLPFC or the ventromedial prefrontal cortex--the vmPFC) to see if applying rTMS to one brain area is more helpful than the other brain area.

NCT ID: NCT05704582 Recruiting - Psychotic Disorders Clinical Trials

RCT Comparing Avatar Intervention to Supportive Intervention to Reduce Cannabis Use in Patients With Psychotic Disorders

AC2
Start date: February 1, 2023
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to conduct a single-blind randomized controlled trial to verify whether the Avatar Intervention has greater efficacy over supportive intervention to reduce cannabis use in patients with psychotic disorders.

NCT ID: NCT05664763 Recruiting - Clinical trials for Cannabis Use Disorder

Understanding Effects of Cannabis Use and Abstinence on Neural Glutamate Homeostasis

Start date: March 1, 2023
Phase: Early Phase 1
Study type: Interventional

This study will be the first in vivo human multimodal neuroimaging study exploring the relationship between mGluR5 availability (PET), neural oscillations (EEG), and cognitive function in people with CUD. The goal is to test the overall hypothesis that mGluR5 availability is higher in people with CUD compared with HC. In Aim 1, the investigators will determine differences in mGluR5 availability between people with CUD and HC in the fronto-limbic brain circuit. Aim 2 examines the associations between mGluR5 availability, CUD severity, neural oscillations, and cognitive function in CUD subjects. Aim 3 will determine how prolonged abstinence from chronic cannabis use affects mGluR5 availability, neural oscillations, and cognitive function in CUD subjects.

NCT ID: NCT05620433 Recruiting - Cannabis Use Clinical Trials

Joint Effort 2.0: a Mobile Application With University Students

JOINTEFFORT
Start date: February 8, 2023
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate quantitatively and qualitatively a mobile application, Joint Effort, targeting safe cannabis use among consumers. This randomized controlled trial is currently conducted on the Joint Effort mobile application.