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Marijuana Abuse clinical trials

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NCT ID: NCT05999344 Recruiting - Clinical trials for Alcohol Use Disorder

Alcohol and Cannabis Concentrates Co-Administration

Start date: December 16, 2021
Phase: N/A
Study type: Interventional

The goal of this study is to learn about the effects of combining alcohol with cannabis concentrate products which contain high levels of THC. The main question[s] it aims to answer are, 1) How does the order in which someone consumes THC and alcohol in a given co-use session impact outcomes such as blood alcohol level, heart rate or subjective drug effects, and 2) how does THC percentage in cannabis influence outcomes following alcohol and cannabis co-administration. Participants will be scheduled for our mobile lab to come to their residence. During the session, they will: - consume a standardized dose of alcohol as well as use their own preferred cannabis concentrate product. - they will then remain in our mobile lab for about 4 hours and complete some surveys as well as do some cognitive tasks on an iPad every 30 minutes. - They will also have their blood drawn three times throughout the session, and will periodically be asked to blood into a breathalyzer to measure blood alcohol level. Researchers will compare people who use alcohol prior to cannabis to those who use cannabis prior to alcohol to determine whether order of use impacts outcomes.

NCT ID: NCT05979272 Recruiting - Cannabis Use Clinical Trials

TECH App Marijuana Use Intervention for Court-Involved Adolescents

TECH
Start date: June 21, 2023
Phase: N/A
Study type: Interventional

The study is about helping teens who are involved in the court system to cut down or quit using marijuana. Teens may be asked to test out an experimental smartphone app, called TECH, that will be used only by teens in this study. This app is a private online community where teens can work towards changing their substance use and other behavior with the help of other anonymous teens. We will use this information to learn how the app may help teens make a change and to improve the TECH app.

NCT ID: NCT05957848 Recruiting - Clinical trials for Cannabis Use Disorder

Guanfacine Extended-release for Adolescents With Cannabis Use

GRACE
Start date: July 27, 2023
Phase: Phase 2
Study type: Interventional

A randomized controlled trial to assess the efficacy of extended-release guanfacine to reduce cannabis use frequency in young people with cannabis use disorder following a period of monitored abstinence.

NCT ID: NCT05885542 Recruiting - Clinical trials for Cannabis Use Disorder

SCORE Emerging Adult Cannabis Use & Stress

Start date: November 1, 2023
Phase: Phase 1/Phase 2
Study type: Interventional

The interface between cannabis use and stress is a particularly important focus for sex differences research in emerging adults. Given the dynamics at play in this critical stage when cannabis use is most prevalent, developmentally informed research is needed to guide tailored clinical interventions. This study will apply rigorous and innovative methods to elucidate sex differences in the nexus of cannabis use and stress among emerging adults with cannabis use disorder to guide the development of tailored treatments.

NCT ID: NCT05873465 Recruiting - Cannabis Use Clinical Trials

Cannabis Use on Sedation for Oral Surgery Procedures

Start date: March 14, 2023
Phase: Phase 4
Study type: Interventional

The use of Cannabis is increasing in the population, and the effects that this might have on different medical procedures are poorly understood. Particularly when submitted to deep sedation or general anesthesia, there is no consensus on best drugs or doses to deliver. The purpose of this clinical trial is to clarify the influence of chronic cannabis use during office based general anesthesia for extraction of teeth. The procedures will be performed in the Oral and Maxillofacial Surgery Clinic at the College of Dentistry.

NCT ID: NCT05868213 Recruiting - Cannabis Clinical Trials

Cannabis Observations on Brain Waves, Retrieval, and Attention: Experiment 1

COBRA
Start date: August 17, 2022
Phase:
Study type: Observational

This study investigates the impact of ∆9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on recognition memory in healthy, regular cannabis users. Participants complete the same recognition memory task after self-administering one of three different strains of cannabis flower one day and while not intoxicated another day. Event-related potentials (ERPs) are measured via electroencephalogram (EEG) during the recognition memory task. Blood is collected to quantify THC and CBD exposure. Participants also complete self-report measures of medical history, sleep quality, subjective cognitive function, physical activity, psychological functioning, substance use, and acute drug effects.

NCT ID: NCT05859347 Recruiting - Clinical trials for Cannabis Use Disorder

Repetitive Transcranial Magnetic Stimulation for Cannabis Use Disorder

Start date: May 15, 2023
Phase: N/A
Study type: Interventional

There has been a considerable rise in cannabis consumption in recent years, with estimates of 200 million individual users globally. Importantly, 3% of these individuals have cannabis use disorder (CUD), with this prevalence increasing to 33% amongst regular users, making it one of the most common substances use disorders (SUDs) worldwide. CUD is associated with substantial health, societal, and economic costs, and worsening of other psychiatric disorders. Despite this clinical burden, effective treatment options are limited. No pharmacological treatments have emerged as clearly efficacious, and psychotherapeutic interventions have shown tempered results. Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain-based approach in which alternating magnetic fields are applied to the scalp to induce electrical currents in cortical tissue. As it can modulate neural circuits implicated in neuropsychiatric disorders, it is a promising brain-based approach in the treatment of addictions. Evidence has indicated its efficacy in reducing drug craving and consumption across numerous SUDs, although research into cannabis has been largely unexplored. Recently, a novel circular rTMS coil, the MagVenture MMC-140, has been developed with the capacity to modulate both the bilateral prefrontal cortex (PFC) and insula, both of which are implicated in the neurocircuitry of craving and executive function. As such, it shows potential for CUD treatment. This proof-of-concept clinical trial will evaluate the feasibility and tolerability of a 4-week course of rTMS to the PFC/insula using MMC-140 as a treatment for CUD. Feasibility of both high frequency (HF; excitatory) and low frequency (LF; inhibitory) stimulation parameters will be evaluated. In addition, pre/post rTMS changes in cannabis use outcomes (e.g., consumption, craving, and withdrawal), executive function, and PFC/insula functional connectivity will be explored. By comprehensively investigating clinical, cognitive, and neuroimaging effects of rTMS, this study could pave the way for the first brain-based intervention in CUD that could be widely adopted into clinical settings using a novel, cost-effective and accessible rTMS device.

NCT ID: NCT05855668 Recruiting - Clinical trials for Alcohol Use Disorder

Phenotyping Patients With Alcohol and Cannabis Use Disorders Using the Addictions Neuroclinical Assessment

Start date: November 10, 2022
Phase: N/A
Study type: Interventional

This 2-arm study will recruit participants with 1) alcohol use disorder and 2) cannabis use disorder for a 12-week cognitive behavioral therapy, following a thorough baseline assessments on executive function, incentive salience, and negative emotionality.

NCT ID: NCT05849636 Recruiting - Adolescent Behavior Clinical Trials

Alerta Cannabis: Evaluation of Web-based Tailored Intervention

NOTCANNABIS
Start date: October 1, 2022
Phase: N/A
Study type: Interventional

This study consists in the the design, implementation, and evaluation of the first web-based computer tailored intervention program aimed at the prevention of cannabis use in Spanish adolescents (ALERTA CANNABIS). A Cluster Randomized Controlled Trial is conducted to test the effectiveness of ALERTA CANNABIS in students aged 14 to 18 years across 34 high schools from Andalusia (southern Spain), which are randomized either to the experimental or the control condition (EC and CC).

NCT ID: NCT05833230 Recruiting - Cannabis Use Clinical Trials

Investigating Real-world Stress-related Mechanisms in Heavy Cannabis Users

CLR2
Start date: June 1, 2023
Phase: N/A
Study type: Interventional

This research project proposes a novel approach to elucidate the biological adaptations associated with heavy cannabis use and to assess whether such adaptations are predictive of higher cannabis craving in response to both cannabis cues and stressors.