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Clinical Trial Summary

The aim of this study is to assess the impact of ketamine on aesthetic perception and processing. This study assesses the role of these effects in facilitating ketamine's antidepressant properties, with a focus on anhedonia. To address this aim, 25 patients with major depressive disorder and 35 healthy controls will be assessed twice with magnetic resonance imaging, once after administration of intravenous ketamine (subanesthetic dose) and once after administration of placebo.This study has a single-center, placebo-controlled, cross-over study design. During MRI, structural, resting state, and functional imaging will be performed. Functional imaging will comprise aesthetic processing, reward, and sexual arousal paradigms. In addition, various neuropsychological scales assessing depressive symptoms, anhedonia, and aesthetic processing will be performed. Eligibility for participation will be assessed during a screening visit, a follow up visit will end study participation.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05320107
Study type Interventional
Source Medical University of Vienna
Contact Rupert Lanzenberger, MD
Phone 0043 1 40400
Email rupert.lanzenberger@meduniwien.ac.at
Status Recruiting
Phase Phase 1
Start date June 1, 2022
Completion date February 28, 2025

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