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Gut Feeling: Understanding the Mechanisms Underlying the Antidepressant Properties of Probiotics — PROMEX  

Major Depressive Disorder Clinical Trial

Official title:
Gut Feeling: Understanding the Mechanisms Underlying the Antidepressant Properties of Probiotics

Clinical Trial Summary

Previous research has suggested that probiotics can improve depressive symptoms in patients with Major Depressive Disorder (MDD), particularly when used in addition to antidepressants. The aim of this exploratory pilot study is to improve the investigator's understanding of the mechanisms underlying these effects. This study will assess the effects of an 8-week double-blind placebo-controlled probiotic intervention on the gut microbiome, inflammatory marker levels, brain activity and neurotransmitter levels in patients with MDD and their relationship to changes in mood. This study will also recruit a group of demographically-matched healthy controls for gut microbiome comparison with the MDD group (non-interventional).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03893162
Study type Interventional
Source King's College London
Contact
Status Completed
Phase N/A
Start date July 1, 2019
Completion date June 30, 2022
View Details
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