Event Related Potentials in Borderline Personality Disorder and Major Depression

Major Depression Clinical Trial

Official title:

Event Related Potentials in Borderline Personality Disorder and Major Depression

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT01469663
• Other study ID #: 5910
• Status: Terminated
• Start date: July 2011
• Est. completion date: March 2015

Study information

• Verified date: May 2021
• Source: State University of New York - Upstate Medical University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This study examines whether depression in people with borderline personality disorder is different than depression in people without borderline personality disorder. Unlike people who have depression alone (i.e. without borderline personality disorder), people with borderline personality disorder have depressions that often do not improve with medications. This makes treating depression much more challenging in someone with borderline personality disorder than without borderline personality disorder. Borderline personality disorderis associated with difficulty in understanding and communicating feelings. Impaired emotion processing may reflect dysfunction of an area of the brain, the anterior cingulate. Depression is associated with changes in anterior cingulate activity. The investigators believe that when borderline personality disorder is present with depression, brain activity changes in the anterior cingulate will not be the same as in depressed patients without borderline personality disorder. An electroencephalogram records brain electrical activity. In this study, the investigators will measure electroencephalogram indices reflecting anterior cingulate activity. HYPOTHESIS: In this study, the investigators predict that when borderline personality is present with depression, electroencephalogram indices of anterior cingulate activity will be different from when depression is present alone (without borderline personality). This could help to explain why people with borderline personality have depressions that are harder to treat than depressions in people without borderline personality. The investigators also predict that electroencephalogram indices of the anterior cingulate will reflect emotional processing ability, as measured by validated questionnaires.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 30
• Est. completion date: March 2015
• Est. primary completion date: March 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 18 Years to 45 Years

Eligibility

Inclusion Criteria:

• age between 18 and 45
• female
• noncontrols diagnosis: major depression &/or borderline personality disorder
• Control participants should have neither major depression or borderline pers.
• meet Structured Controlled Interview for DSM - II cut off scores
• meet Beck Depression Inventory (BDI)cut off scores
• meet Borderline Evaluation of Severity Over Time(BEST) cut off scores.

Exclusion Criteria:

• based on having none of the below diagnoses from patient history, prior clinical records and based on MINI Plus International Neuropsychiatry Interview
• schizophrenia
• psychosis
• Attention Deficit Hyperactivity Disorder
• Obsessive Compulsive Disorder
• bipolar disorder
• mental retardation
• dementia
• CNS disease
• Post-Traumatic Stress Disorder in non-borderline personality disorder groups
• Recreational drug or alcohol use in the past week.

Related Conditions & MeSH terms

• Borderline Personality Disorder
• Depression
• Depressive Disorder
• Depressive Disorder, Major
• Disease
• Major Depression
• Personality Disorders

Locations

Country	Name	City	State
United States	Syracuse University - CNY Medical Center	Syracuse	New York
United States	Upstate Medical University	Syracuse	New York

Sponsors (2)

Lead Sponsor	Collaborator
State University of New York - Upstate Medical University	Syracuse University

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Error related negativity amplitude	electroencephalogram amplitude of the error related negativity	on day 1 and then 4 weeks (average) later
Primary	N2 amplitude	electroencephalogram amplitude of N2 wave	on day 1 and then 4 weeks (average) later