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Reduction of SystemiC Inflammation After Ischemic Stroke by Intravenous DNase Administration (ReSCInD) — ReSCInD  

Ischemic Stroke Clinical Trial

Official title:
Reduction of SystemiC Inflammation After Ischemic Stroke by Intravenous DNase Administration (ReSCInD)

Clinical Trial Summary

The goal of this (monocentric, randomised, placebo-controlled single-blinded; phase 2) clinical trial is to test the hypothesis that DNase 1 administration leads to a reduction in systemic immune response measured in patients after acute ischaemic stroke compared to control treatment. Participants will receive intravenous DNase 1 (500 µg/kg) or placebo (NaCl 0.9%) twice within 24±6 hours after symptom onset (last seen well). Blood samples will be taken at baseline, day 1 and 3. Personal visits will occur on baseline, day 1, 3 and discharge date. A telephone interview will be conducted on day 30±3.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05880524
Study type Interventional
Source Ludwig-Maximilians - University of Munich
Contact Arthur Liesz, Prof. Dr.
Phone +49 89 4400 46242
Email arthur.liesz@med.uni-muenchen.de
Status Not yet recruiting
Phase Phase 2
Start date December 2024
Completion date January 2026
View Details
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