Ischemic Stroke Clinical Trial
Official title:
Precise Antiplatelet THerapy Guided by Platelet Aggregation Function in Acute Ischemic STROKE
Objectives of Study:To explore the efficacy and safety of antiplatelet therapy in patients with non-cardiogenic cerebral infarction under the guidance of platelet aggregation function.
Non cardiogenic cerebral infarction accounts for more than 50% of cerebral infarction, and the key to its onset is an increase in platelet aggregation function. Aspirin is an IA recommended drug for the prevention and treatment of non cardiogenic cerebral infarction. However, after taking aspirin and clopidogrel regularly, more than 30% of stroke patients still experience ischemic events (aspirin resistance, clopidogrel resistance), leading to stroke recurrence. Aspirin is the main antiplatelet drug for the prevention and treatment of non cardiogenic cerebral infarction. Therefore, clinical research on aspirin resistance in the prevention and treatment of non cardiogenic cerebral infarction is of great significance, which can help partially solve the bottleneck of antiplatelet therapy resistance in cerebral infarction. Platelet aggregation function testing can timely detect resistance to antiplatelet therapy, guide drug adjustments, and researchers will compare the experimental group (receiving precise antiplatelet therapy) with the control group (blindly taking aspirin) to see if the experimental group will reduce stroke recurrence or mortality, in order to prevent and treat cerebral infarction with aspirin and clopidogrel resistance and reduce the recurrence rate of cerebral infarction. ;
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