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Intracerebral Hemorrhage clinical trials

View clinical trials related to Intracerebral Hemorrhage.

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NCT ID: NCT05687201 Active, not recruiting - Clinical trials for Intracerebral Hemorrhage

Effect of Apolipoprotein E on the Prognosis of Patients With Intracerebral Hemorrhage

Start date: January 1, 2020
Phase:
Study type: Observational

The purpose of this observational study was to compare perihematomal edema and short-term prognosis in patients with intracerebral hemorrhage carrying the APOE-ε3 and APOE-ε4 genes. The main questions it aims to answer are: - Exploring whether patients carrying the ApoE-ε4 gene have more perifocal perihematomal edema after intracerebral hemorrhage than patients with the ApoE-ε3 gene. - ApoEε4 gene has worse short-term prognosis than ApoEε3 gene in intracerebral hemorrhage patients. All the patients in this study received the same medications based on the guidelines for the management of hypertensive intracerebral hemorrhage.Some ICH patients were evaluated for Stereotactic minimally invasive surgery (sMIS) treatment by two experienced neurosurgeons.

NCT ID: NCT04951453 Active, not recruiting - Clinical trials for Traumatic Brain Injury

Systemic Nitrosative/Oxidative Stress in Patients With Acute Brain Injury

NOX
Start date: August 18, 2021
Phase:
Study type: Observational

Acute brain injury due to traumatic brain injury (TBI), intracerebral haemorrhage (ICH), and aneurysmal subarachnoid haemorrhage (SAH) carries a high morbidity and mortality, in part due to the development of secondary brain injury. The mechanisms behind secondary brain injury are incompletely understood, but oxidative/nitrosative stress and disturbances in the metabolism of the vasodilator nitric oxide (NO) are believed to be involved. The aim of the present study is to characterise systemic changes in markers of oxidative/nitrosative stress and NO metabolism in the early phase after acute brain injury, and to examine their relationship to clinical course, neurological outcome, and mortality.

NCT ID: NCT04522102 Active, not recruiting - Clinical trials for Intracerebral Hemorrhage

Antiplatelet Secondary Prevention International Randomised Trial After INtracerebral haemorrhaGe (ASPIRING)-Pilot Phase

Start date: September 3, 2021
Phase: Phase 3
Study type: Interventional

ASPIRING is an investigator-led, multicentre, prospective, randomised, open-label, blind outcome (PROBE), parallel group, clinical trial. The pilot phase will explore the feasibility of conducting a trial of starting antiplatelet monotherapy versus avoiding antiplatelet therapy for reducing all serious vascular events for adults surviving symptomatic stroke due to spontaneous intracerebral haemorrhage (ICH). The pilot phase will involve ~120 patients at ~30 hospitals in China, Australia and New Zealand.

NCT ID: NCT04088630 Active, not recruiting - Clinical trials for Intracerebral Hemorrhage

Fingolimod as a Treatment of Cerebral Edema After Intracerebral Hemorrhage

FITCH
Start date: August 7, 2020
Phase: Early Phase 1
Study type: Interventional

The purpose of this study is to test the safety and effectiveness of a single dose of fingolimod in patients with primary spontaneous intracerebral hemorrhage (ICH).

NCT ID: NCT03425305 Active, not recruiting - Heart Failure Clinical Trials

Serum Uric Acid Levels and Onset of Cardiovascular Diseases: a CALIBER Study

Start date: January 1998
Phase: N/A
Study type: Observational

Serum uric acid level is a commonly measured biomarker. The association between serum uric acid level and the risk of developing cardiovascular diseases has been observed in some studies, while others showed controversial results. Estimation of this association may help to predict cardiovascular outcomes and may guide new treatment strategies. The hypothesis is that increased serum uric acid level is associated with a range of cardiovascular diseases.

NCT ID: NCT03342664 Active, not recruiting - Clinical trials for Intracerebral Hemorrhage

MIND: Artemis in the Removal of Intracerebral Hemorrhage

Start date: February 7, 2018
Phase: N/A
Study type: Interventional

The primary objective of this multicenter randomized controlled study is to compare the safety and efficacy of minimally invasive hematoma evacuation with the Artemis Neuro Evacuation Device to best medical management for the treatment of intracerebral hemorrhage (ICH).

NCT ID: NCT03243539 Active, not recruiting - Stroke Clinical Trials

Implementation of Neuro Lung Protective Ventilation

NEUROVENT
Start date: August 31, 2017
Phase: N/A
Study type: Interventional

Patients who experience lung injury are often placed on a ventilator to help them heal; however, if the ventilator volume settings are too high, it can cause additional lung injury. It is proven that using lower ventilator volume settings improves outcomes. In patients with acute brain injury, it is proven that maintaining a normal partial pressure of carbon dioxide in the arterial blood improves outcomes. Mechanical ventilator settings with higher volumes and higher breathing rates are sometimes required to maintain a normal partial pressure of carbon dioxide. These 2 goals of mechanical ventilation, using lower volumes to prevent additional lung injury but maintaining a normal partial pressure of carbon dioxide, are both important for patients with acute brain injury. The investigators have designed a computerized ventilator protocol in iCentra that matches the current standard of care for mechanical ventilation of patients with acute brain injury by targeting a normal partial pressure of carbon dioxide with the lowest ventilator volume required. This is a quality improvement study with the purpose of observing and measuring the effects of implementation of a standard of care mechanical ventilation protocol for patients with acute brain injury in the iCentra electronic medical record system at Intermountain Medical Center. We hypothesize that implementation of a standardized neuro lung protective ventilation protocol will be feasible, will achieve a target normal partial pressure of carbon dioxide, will decrease tidal volumes toward the target 6 mL/kg predicted body weight, and will improve outcomes.

NCT ID: NCT02946866 Active, not recruiting - Clinical trials for Intracerebral Hemorrhage

CoHOrt of Cerebral CavernOus maLformATion: multicEnter Prospective Observational Study

CHOCOOATE
Start date: June 2016
Phase:
Study type: Observational

The aim of this prospective study is to reveal the natural history of symptomatic hemorrhage in adult patients with cerebral cavernous malformation with the goal of informing the treatment plan.

NCT ID: NCT02830152 Active, not recruiting - Stroke Clinical Trials

Prevention of Stroke by Left Atrial Appendage Closure in Atrial Fibrillation Patients After Intracerebral Hemorrhage

Start date: May 3, 2017
Phase: N/A
Study type: Interventional

Intracerebral hemorrhage (ICH) in patients with non-valvular atrial fibrillation (NVAF) poses a particular dilemma for thromboprophylaxis. Left atrial appendage occlusion (LAAO) is a non-pharmacological approach to prevent cardiac embolism in NVAF. The risk-benefit ratio of LAAO in patients with NVAF after ICH is unknown. The aim of STROKECLOSE is to assess the effect of LAAO to reduce the incidence stroke, bleeding and cardiovascular mortality in patients with NVAF and prior ICH.

NCT ID: NCT01856699 Active, not recruiting - Ischemic Stroke Clinical Trials

Superficial Siderosis in Patients With Suspected Cerebral Amyloid Angiopathy

SuSPect-CAA
Start date: May 2013
Phase: N/A
Study type: Observational

Aim of the SuSPect-CAA study is to prospectively evaluate the prognostic significance of cortical superficial siderosis in patients with suspected cerebral amyloid angiopathy with a primary focus on future stroke and mortality.