Insulin Resistance Clinical Trial
Official title:
Relative Sarcopenia and Cardiometabolic Risk in Young Adults With Obesity
Verified date | January 2024 |
Source | Massachusetts General Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The goal of this research study is to learn more about the hormones that muscles make during exercise, and if those hormones are associated with type 2 diabetes risk in adults who are overweight or obese. Participants will undergo exercise testing on an upright bicycle, with blood samples taken for muscle hormones before and after exercise. The hypothesis is that adults with overweight/obesity and insulin resistance will have an impaired muscle hormone profile in response to exercise compared to adults with overweight/obesity who are not insulin resistant.
Status | Completed |
Enrollment | 28 |
Est. completion date | November 17, 2021 |
Est. primary completion date | November 17, 2021 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 70 Years |
Eligibility | Inclusion Criteria: - Previously enrolled in protocol 2004P000013 or protocol 2012P002276, which had overweight or obesity as inclusion criteria - Ability to walk up 3 flights of stairs and 3 city blocks (to ensure ability to complete exercise testing) Exclusion Criteria: - Unstable heart or lung disease - Exercise >150 minutes/week - Participation in college sports |
Country | Name | City | State |
---|---|---|---|
United States | Massachusetts General Hospital | Boston | Massachusetts |
Lead Sponsor | Collaborator |
---|---|
Massachusetts General Hospital |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Percent Change in Serum Myostatin Levels From Pre- to 3 Hours Post-exercise | Percent change in serum myostatin levels from pre- to 3 hours post-cardiopulmonary exercise test | Pre- to 3 hours post-exercise | |
Secondary | Percent Change in Serum Myostatin Levels From Pre- to 2 Hours Post-exercise | Percent change in serum myostatin levels from pre- to 2 hours post-cardiopulmonary exercise test | Pre- to 2 hours post-exercise | |
Secondary | Percent Change in Serum Myostatin Levels From Immediately Post to 2 Hours Post-exercise | Percent change in serum myostatin levels from immediately post to 2 hours post-cardiopulmonary exercise test | Immediately post to 2 hours post-exercise |
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