Hypertension Clinical Trial
Official title:
Effect of Bariatric Surgery on Fatty Liver Disease. A Prospective One-Year Follow-Up Study
The study is based on data from morbidly obese patients who fulfilled the criteria for bariatric surgery during 2016-2018 at the Department of Surgery, University Hospital Ostrava, Czech Republic.
The study is based on data from morbidly obese patients who fulfilled the criteria for
bariatric surgery during 2016-2018 at the Department of Surgery, University Hospital Ostrava,
Czech Republic. Patients with age above 18 years, BMI > 35-40 kg/m2, and associated with at
least one of the complications including hypertension, diabetes, and failure of the current
therapies to relieve the symptoms were included in the study. Patients included in the
current study do not have a history of excessive alcohol consumption, use of hepatotoxic
drugs, infectious liver diseases (i.e. hepatitis A, B, C), and genetic hemochromatosis. A
total of 72 patients including n = 26 during 2016, n = 26 during 2017, and n = 20 during 2018
who qualified for bariatric surgeries were included in this observational study. Data related
to patients' gender, age (years), weight (kg), height (cm), and associated co-morbidities
like diabetes and hypertension were recorded before surgery. BMI (kg/m2), biochemical
parameters including triglycerides profile (mmol/L), platelet count (number/L), Gamma
glutamyl-transferase (international units - IU/L), albumin concentration (g/L), Alanine
amino-transferases (units/L), Aspartate aminotransferases (international units - IU/L), were
evaluated following standard procedures. Platelet count, triglycerides, and enzymes were
determined using standard procedures.
The biochemical results were compared to the corresponding paired values before surgery and
after surgery. The current study was designed to prospectively investigate the effect of
bariatric surgeries among non-alcoholic obese individuals from 2016-2018 and one year follow
up on liver biochemistry, BMI, non-alcoholic fatty liver disease (NAFLD) fibrosis score,
Fibrosis 4 (FIB 4) Index, and Fatty Liver Index (FLI).
The continuous variables were expressed as mean ± standard deviation and median
(interquartile range) in case of normal and non-normal distribution, respectively. The
Shapiro-Wilk test was used to test for normal distribution. The within-patient changes in
clinical parameters (continuous or ordinal variables) from baseline to 1-year after bariatric
surgery were compared using the Wilcoxon matched-pairs signed-rank tests for ordinal
variables and continuous variables when the change was not normal or using the paired
Student's t-test otherwise. The statistical testing was done at the two-tailed α level of
0.05. The data were analyzed using GraphPad Prism Version 8.0.2 (GraphPad Software, Inc.,
USA).
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