Hypertension Clinical Trial
Official title:
Short-term Effects of Perindopril-amlodipine Versus Perindopril-indapamide on Blood Pressure Control in Newly Diagnosed Type 2 Diabetes Individuals With Hypertension
Verified date | November 2018 |
Source | Yaounde Central Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
This was a double-blinded randomized controlled trial of 24-hour blood pressure control in sub Saharan type 2 diabetes patients, newly diagnosed for hypertension. They were allocated to receive either a fixed combination of perindopril + amlodipine or perindopril + indapamide for 42 days.
Status | Completed |
Enrollment | 30 |
Est. completion date | May 30, 2017 |
Est. primary completion date | May 30, 2017 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 25 Years to 65 Years |
Eligibility |
Inclusion Criteria: - adult diabetes patients aged between 25-65 years, - with grade I or grade II (WHO classification) hypertension on the clinical measure, confirmed by ABPM - naïve to any anti-hypertensive treatment - written informed consent. Exclusion Criteria: - Patients with grade III hypertension (WHO classification) were classified as hypertensive emergency, - estimated creatinine clearance ?30ml/min/1.73m2 (using Modified Diet in Renal Diseases formula) - alanine transaminase (ALT)= 3 normal - any contraindication to study drugs (hypersensitivity) - pregnant or breastfeeding women |
Country | Name | City | State |
---|---|---|---|
Cameroon | National Obesity Centre, Yaounde Central Hospital | Yaounde | Centre |
Lead Sponsor | Collaborator |
---|---|
Yaounde Central Hospital | University of Yaounde 1 |
Cameroon,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | 24-hour blood pressure | Change in average 24-hour blood pressure | 6 weeks | |
Secondary | night blood pressure dip | Change in average night time blood pressure drop | 6 weeks |
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