Hypertension Clinical Trial
Official title:
Short-term Effects of Perindopril-amlodipine Versus Perindopril-indapamide on Blood Pressure Control in Newly Diagnosed Type 2 Diabetes Individuals With Hypertension
This was a double-blinded randomized controlled trial of 24-hour blood pressure control in sub Saharan type 2 diabetes patients, newly diagnosed for hypertension. They were allocated to receive either a fixed combination of perindopril + amlodipine or perindopril + indapamide for 42 days.
This was a double-blinded randomized controlled trial conducted at the National Obesity
Center and the cardiology unit of the Yaoundé Central Hospital in Cameroon from October 2016
to May 2017. Eligible patients were type 2 diabetes patients, newly diagnosed for
hypertension (grade I or II) with confirmation on ambulatory BP monitoring (ABPM). Patients
were either on lifestyle modification alone or on a stable anti-diabetic treatment for the
past three months, aged 25-65 years naïve to any anti-hypertensive treatment, who provided
their written informed consent. Participants were assigned to receive as anti-hypertensive
treatment perindopril-amlodipine once daily or perindopril-indapamide at the same frequency.
The two groups were followed up and monitored for sixth weeks and patients did not take any
additional treatment with BP modifying properties.
The primary outcome was the relative change in circadian blood pressure profile between the
two groups after six weeks of treatment
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