Hypertension Clinical Trial
To study relationships among lipoprotein metabolism, hypertension, and hyperinsulinemia-insulin resistance in African American males and females. The study was part of a Collaborative Project on Minority Health which investigated the mechanisms by which insulin contributes to cardiovascular disease.
BACKGROUND:
The study was part of the initiative "Collaborative Projects (R01s) on Minority Health". The
concept for the initiative was developed by the NHLBI staff after the 1993 Report of the
Committee on Appropriations, House of Representatives, encouraged the NHLBI to establish
minority centers to facilitate the diagnosis and treatment of cardiovascular diseases. The
initiative was approved at the September 1992 National Heart, Lung, and Blood Advisory
Council and released in October 1992.
Julian Marsh was one of three investigators in a collaborative program with Bonita Falkner
as Program Coordinator.
DESIGN NARRATIVE:
In a sub-set of subjects with either high or low plasma insulin levels after a glucose
challenge (insulin sensitive or insulin resistant), the investigators determined the
fractional and absolute synthesis and catabolic rates of apolipoproteins B and A-I, the
dominant lipoproteins of Low Density Lipoprotein (LDL) and High Density Lipoprotein (HDL).
They used stable isotopes and multicompartmental kinetic analysis following an oral bolus
dose of deuteroleucine. They hypothesized that in hypertensive African Americans with
hyperinsulinemia, more of the smaller Very Low Density (VLDL) particles are secreted and
converted to LDL.
The study completion date listed in this record was obtained from the "End Date" entered in
the Protocol Registration and Results System (PRS) record.
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