Hyperlipidemias Clinical Trial
Official title:
Investigate Effect on Mean IMT of Probucol And/or CilosTazol in Patients With Coronary Heart dIsease Taking HMGCoA Reductase Inhibitor Therapy: A Randomized, Multicenter, Multinational Study
The purpose of this study is to evaluate the additional effect of probucol or concomitant administration of cilostazol and probucol on mean carotid artery intima-media thickness (mean IMT) at year 1, 2, and 3.
Hyperlipidemic patients who are currently receiving HMGCoA reductase inhibitors(Statins) will
be randomized Group A(Control), Group B(Probucol only added group) or Group C(Probucol and
cilostazol added group) . Randomization will be done by the minimization method, controlling
for the following factors: Country(Korea vs China) and max IMT (≥2.0mm vs.<2.0mm).
Group A : HMGCoA reductase inhibitor continued
Group B : HMGCoA reductase inhibitor continued + Probucol 250 mg PO, BID
Group C : HMGCoA reductase inhibitor continued + Probucol 250 mg PO, BID +Cilostazol 100 mg
PO, BID
;
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