Congestive Heart Failure Clinical Trial
Systemic sclerosis is an orphan, multiorgan disease affecting the connective tissue of the
skin and all internal organs. Cardiac involvement, mainly characterised by small
intramyocardial coronary artery involvement and myocardial fibrosis, can cause the
development of impaired diastolic ventricular filling, cardiac blocks and ventricular
arrhythmias, and can ensue in congestive heart failure and sudden death. Until now, no drug
has been proven to have a therapeutic effect on SSc myocardial disease on an evidence-based
level. Short-term trials and retrospective studies have suggested a favourable and
protective effect of calcium channel blockers and angiotensin converting enzyme inhibitors
in patients with myocardial involvement. However, no data are presently available on the
prevention and treatment of severe heart disease.
This observational trial is part of the collaborative project "DeSScipher", one out of five
observational trials to decipher the optimal management of systemic sclerosis. Aim of this
observational trial is to assess the efficacy and safety of calcium channel blockers and
angiotensin converting enzyme inhibitors in asymptomatic SSc patients with cardiac
involvement.
n/a
Observational Model: Cohort, Time Perspective: Prospective
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