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Prolonged Fasting on Glucose Metabolism and Hormonal Regulation in Healthy, Obese and Subjects With Type 2 Diabetes — PROLOG  

Healthy Clinical Trial

Official title:
The Effects of Prolonged Fasting on Glucose Metabolism and Hormonal Regulation in Healthy, Obese and Subjects With Type 2 Diabetes

Clinical Trial Summary

In a previous study investigating the effects of intermittent fasting, our research group found evidence for higher glucose excursions and a reduced insulin response after a 36 hour fasting period as compared to an overnight fasting period in healthy subjects. The aim of this research project is to investigate the effect of short and midterm fasting (12 hours versus 36 hours) on glucose metabolism, glucose regulatory hormones, insulin secretion and resting energy expenditure in healthy and obese people as well as in patients with type 2 diabetes.

Clinical Trial Description

In this clinical study, we want to examine the effects of different fasting periods (12 hours versus 36 hours) on blood sugar levels and other metabolic parameters and hormones. For this the following investigations are carried out: - Oral glucose tolerance test with detailed laboratory evaluation - Bio-impedance measurement to determine body composition (muscle and fat mass) The examinations are carried out on 4 different cohorts (normal healthy persons, obese patients, patients with type 2 diabetes and patients with type 1 diabetes). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04283318
Study type Interventional
Source Medical University of Graz
Contact
Status Completed
Phase N/A
Start date June 13, 2018
Completion date February 28, 2022
View Details
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