Heart Failure Clinical Trial
Official title:
Evaluation of Exercise Intolerance and Right Heart Function in Patients With Heart Failure and Pulmonary Vascular Disease
Heart Failure with Preserved Ejection Fraction (HFpEF) and Pulmonary Hypertension (PH) can be diagnosed noninvasively by Exercise Echocardiography (ExE) and Cardiopulmonary Exercise Testing (CPX) as compared with gold standard invasive hemodynamic assessment.
- The broad objective of this proposal is to characterize the dynamic changes in
cardiopulmonary mechanics during stress in patients with exertional dyspnea,
establishing a comprehensive multimodality diagnostic approach to the evaluation of
exercise intolerance.
- The specific objective is to prospectively compare established and novel parameters
derived from echocardiography and CPX with simultaneous, gold standard invasive
measures of cardiovascular hemodynamics at rest and with exercise stress to define the
role of noninvasive testing in the diagnostic workup.
- The primary hypothesis is that combined ExE and CPX can noninvasively identify HFpEF.
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Observational Model: Cohort, Time Perspective: Prospective
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