Endothelial Function Clinical Trial
Official title:
Pioglitazone Regress Left Ventricular Mass in Type 2 Diabetes With Ischeamia Heart Disease
Cardiovascular complications account for the highest mortality in type 2 diabetic patients,
mainly due to ischeamia heart disease (IHD). Most of the attention in treating IHD in type 2
diabetes is understandably directed toward treating coronary artery conditions. However
there are other treatable culprits in these patients.
Left ventricular hypertrophy (LVH) is widespread in type 2 diabetic patients with IHD, even
in the absence of hypertension. It is a strong predictor of cardiovascular events and
all-cause mortality. In one study, the presence of LVH was a stronger predictor of mortality
than either multivessel coronary disease or impaired left ventricular function. Regression
of LVH has been associated with an improved prognosis, independent of change in blood
pressure (BP). Therefore, cardiovascular events and mortality in type 2 diabetes with IHD
might will be reduced if we can find novel therapies to regress LVH.
Pioglitazone can improve atherosclerosis. Therefore, we hypothesied that pioglitazone can
regress the left ventricular mass (LVM) in type 2 diabetes with IHD.Therefore, in this
study, we will treat patients with pioglitazone, and we will also metformin as control.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03301402 -
Air Purifier to Improve Endothelial Function and Carotid Intima Thickness
|
N/A | |
| Recruiting |
NCT02500329 -
Effect of Gemigliptin or Acarbose on Endothelial Function in Type 2 DM Patients
|
Phase 4 | |
| Completed |
NCT01028599 -
Effect of Physical Training on Oxygen Uptake and Endothelial Function in Heart Transplant Recipients
|
N/A | |
| Completed |
NCT00575120 -
Endothelial Function Assessed With BOLD-MRI
|
N/A | |
| Recruiting |
NCT05451641 -
Blood Flow Restriction Resistance Training Intervention on Vascular Function
|
N/A | |
| Completed |
NCT01713374 -
Physiological Assessment of the Endothelium - Circadian Rhythm and Role of the Sympathetic Nervous System
|
N/A | |
| Completed |
NCT03651713 -
Hyperglycemia, Exercise, and Endothelial Function
|
N/A | |
| Completed |
NCT00844714 -
Cardiovascular Risk Markers in Patients With Rheumatoid Arthritis: Effect of Rituximab Therapy
|
N/A | |
| Completed |
NCT00967252 -
Impact of Chronic Statin Use During Surgery on Inflammation and Infection Rates
|
N/A | |
| Completed |
NCT01256957 -
Effect of HEPA Air Filters on Subclinical Markers of Cardiovascular Health
|
N/A | |
| Completed |
NCT00845013 -
Epidemiology and Pathogenesis of HIV-Associated Pulmonary Hypertension
|
||
| Completed |
NCT00728221 -
Evaluation and Standardization of Ginseng and it's Components for Blood Pressure Regulation
|
Phase 2 | |
| Completed |
NCT00534651 -
Paracetamol and Endothelial Function in Patients With Stable Coronary Artery Disease
|
Phase 4 | |
| Recruiting |
NCT04689477 -
Non-invasive Characterization of Systemic Microvascular Reactivity by Near-infrared Diffuse Optical Spectroscopy in COVID-19 Patients
|
||
| Completed |
NCT01829542 -
Dose-dependent Effects of Blueberry Polyphenols on Endothelial Function in Healthy Individuals
|
N/A | |
| Completed |
NCT01610401 -
The Metformin-FMD Trial
|
Phase 4 | |
| Terminated |
NCT00942643 -
Endothelial Damage and Atherosclerosis in Obstructive Sleep Apnea
|
N/A | |
| Completed |
NCT05235958 -
VascuFit: Exercise and Vascular Aging
|
N/A | |
| Not yet recruiting |
NCT06288828 -
The Efficacy of Aerobic Exercise Training on Autonomic Nervous System and Endothelial Function in Patients With Compensated Cirrhosis
|
N/A | |
| Completed |
NCT05396079 -
Effect of Tahini in Oxidative Stress and Endothelial Function in Diabetes
|
N/A |