Diastolic Heart Failure Clinical Trial
Official title:
Dietary Approaches to Stop Hypertension in 'Diastolic' Heart Failure 2 (DASH-DHF 2)
The purpose of this study is to examine how dietary changes affect the heart and blood vessels in patients with hypertension (high blod pressure) who have a condition called 'heart failure with preserved ejection fraction" (HFPEF). This condition is also known as "diastolic heart failure" or "heart failure with normal ejection fraction", and occurs even though the heart's pumping function is normal.
In an earlier study, the investigators found that patients with HFPEF who ate a special diet
for three weeks had improved blood pressure control and lower levels of blood chemicals that
may damage the heart and blood vessels. The eating plan in the study was based on the DASH
diet, also known as the Dietary Approaches to Stop Hypertension diet. This plan is rich in
fruits, vegetables, and low-fat dairy, and is recommended to decrease blood pressure in
patients with hypertension. Current medical guidelines also recommend that both patients with
hypertension and those with heart failure should decrease their dietary salt intake.
The diets that patients will eat in this study are the DASH/sodium-restricted (DASH/SRD) diet
as well as a control diet based on the average reported diet collected using Food Frequency
Questionnaires during our pilot study. Patients will be randomized to one diet for three
weeks and then crossover to the other diet for three weeks. Patients will then be asked to
eat the DASH/sodium-restricted diet on their own at home with dietary support for an
additional eight weeks.
In this study, the main goal is to confirm the findings of our earlier study. The
investigators would also like to understand how the DASH/SRD changes the function of the
heart and blood vessels during exercise and the activity of genes that could be involved in
HFPEF.
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