Acute Changes in Plasma Glucose and Cardiovascular Disease in Diabetes

Diabetes Clinical Trial

Official title: Myocardial Work and Left Ventricular Mechanical Dyssynchrony During Acute Changes in Plasma Glucose in Individuals With Type 1 Diabetes, Type 2 Diabetes and Without Diabetes

Status Active, not recruiting

Clinical Trial Summary

Patients with diabetes have an increased risk of sudden cardiac death compared to the general population. Severe hypoglycemia is associated with an increased risk of cardiovascular (CV) disease (CVD) and events, including cardiac arrhythmias and sudden cardiac death; likewise, increased glycemic variability is associated with macrovascular complications and increased mortality. The physiological mechanisms linking hypoglycemia and glycemic variability to CVD and CV events remain unclear.

Myocardial work and mechanical dyssynchrony will be measured by speckle tracking echocardiography during euglycemia, hypoglycemia and hyperglycemia in individuals with type 1 diabetes, type 2 diabetes, and without diabetes. Echocardiographic images from three experimental clamp studies - Hypo-Heart 1 (sub-study 1), Hypo-Heart 2 (sub-study 2) and Rapid-Heart - will be included in this study.

Clinical Trial Description

The results of this study may be compiled into one or more manuscripts for publication.

Study ID's:

Hypo-Heart 1 (sub-study 1): NCT03956173 Hypo-Heart 2 (sub-study 2): NCT03150030 Rapid-Heart:

NCT04800536 ;

Related Conditions & MeSH terms

• Cardiovascular Diseases
• Death
• Death, Sudden, Cardiac
• Diabetes
• Diabetes Mellitus
• Hyperglycemia
• Hypoglycemia
• Sudden Cardiac Death

• NCT number: NCT05500352
• Study type: Interventional
• Source: Steno Diabetes Center Copenhagen
• Status: Active, not recruiting
• Phase: N/A
• Start date: July 1, 2022
• Completion date: December 1, 2023