Effects of Breaking up Prolonged Sitting on Postprandial Cardiometabolic Disease Risk Markers in South Asian Adults

Diabetes Clinical Trial

Official title:

Effects of Breaking up Prolonged Sitting on Postprandial Cardiometabolic Disease Risk Markers in Normal Weight Versus Overweight and Obese South Asian Adults

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03898206
• Other study ID #: 2019ISPAR003
• Status: Recruiting
• Phase: N/A
• Start date: February 26, 2019
• Est. completion date: February 25, 2020

Study information

• Verified date: March 2019
• Source: University of Bedfordshire
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to examine whether breaking up prolonged sitting with short regular bouts of walking can reduce blood sugar and cholesterol levels after eating, which are risk markers for Type 2 diabetes and heart disease. This study will compare these responses in normal weight versus overweight/obese South Asian adults.

Description:

Participants will attend a preliminary testing session where height, weight, body fat and waist circumference will be measured. They will be familiarised with a motorised treadmill that will be used during the experimental visit below and will take part in an exercise test to determine a light-intensity walking speed for the experimental visit.

Participants will then attend two experimental visits in a random order:

1. Prolonged sitting: Participants will remain seated for 5 hours and instructed to reduce excessive movement.

2. Breaking up sitting with walking breaks: Participants will rise from the seated position every 30 minutes throughout the experimental period to walk on a motorised treadmill at a light intensity for 3 minutes. After performing walking activity, they will return to the seated position. In addition, blood sample will be taken at the resting position just before each physical activity bout. The activity breaks will be undertaken on 9 occasions, providing a total of 27 min of light intensity activity.

During each visit, blood pressure will be taken 11 times and blood samples will be taken 10 times. Participants will be given a breakfast and lunch meal to consume.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 66
• Est. completion date: February 25, 2020
• Est. primary completion date: October 25, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• Self-identified South Asian ethnicity.

• Self-report sitting at least 7 hours per day.

• Normal weight, overweight or obese.

Exclusion Criteria:

• Unable to speak and read English.

• Contraindications to performing light-intensity walking.

• Diagnosed cardiovascular disease or diabetes.

Related Conditions & MeSH terms

• Cardiovascular Diseases
• Cardiovascular Risk Factor
• Diabetes
• Physical Activity
• Sedentary Lifestyle

Intervention

Other:
• Breaking up sitting with walking breaks
See Breaking up sitting with walking breaks arm description
• Prolonged sitting
See Prolonged sitting arm description

Locations

Country	Name	City	State
United Kingdom	University of Bedfordshire	Bedford	Bedfordshire

Sponsors (1)

Lead Sponsor	Collaborator
University of Bedfordshire

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Postprandial glucose	Net incremental area under the curve for each 5 h condition will be calculated for glucose	Measured over the 5 hour condition period
Secondary	Postprandial triglycerides	Net incremental area under the curve for each 5 h condition will be calculated for triglycerides	Measured over the 5 hour condition period
Secondary	Postprandial insulin	Net incremental area under the curve for each 5 h condition will be calculated for insulin	Measured over the 5 hour condition period
Secondary	Blood pressure	Mean systolic and diastolic blood pressure over the 5 h conditions	Measured over the 5 hour condition period