Depressive Disorder Clinical Trial
Official title:
Multi-dimensional Diagnosis,Individualized Therapy,and Management Technique for Major Depressive Disorder:Based on Clinical and Pathological Characteristics
Major Depressive Disorder is one of the most common mental diseases,which increases health-care costs and the financial burden to families and societies. Considering its complex clinical symptoms and diversity of comorbidity, depressive disorder's recognition,diagnosis,and antihistone are based on symptomatology,which is lack of multidimensional diagnosis technique based on clinical pathological characteristics,as well as lack of individualized therapy strategy based on quantified evaluation. Besides, other physical diseases,such as nervous system diseases, cardiovascular diseases,endocrine diseases, have the high comorbidity of depressive disorder. However,there is no precise diagnosis technique or standardized therapy strategy. With all those taken into consideration,our study is aimed to adopt E-mental health and m-Health to explore multi-dimensional diagnosis, individualized therapy and management technique based on molecular biology,nerve electrophysiology,and neuroimaging technology etc.
Four parts included in our study:
Part 1:The research, development and verification of indicators based on biomarkers and
clinical characteristics to guide the diagnosis and treatment of depressive disorders
1. to screen biomarkers, to explore its pathophysiology, and to analyze the correlation
between clinical subtypes/characteristics and biomarkers.
2. To differentiate the subtypes of depressive disorder(depression/underload, atypical,
anxiety/somatization) based on clinical symptoms and clinical assessement.
3. To establish personalized therapy strategies,and to explore tool kits for diagnosis and
treatment based on biomarkers and clinical characteristics.
4. to choose appropriate indicators to monitor therapy and side effect by collecting and
analyzing blood/imaging/neuropsychological data.
Part 2: The development,transition and application of hierarchical model diagnostic technique
for physical diseases combined with depressive disorder.
1. to recruit patients with physical diseases combined with depressive disorder, and
explore potential biomarkers.
2. To chose appropriate therapy strategies based on measurement based care(MBC), providing
hierarchical model diagnostic technique for patients.
3. To weigh therapy efficiency and adverse effect among different medicine therapy groups.
Part3: The development and application of comprehensive prevention, diagnosis,and
intervention model of depressive disorder.
1. To explore and establish online screening and assistant diagnosis system for patients
with depressive disorder.
2. research ,development and application of intelligent e-MBC. Part 4: The
development,transition and application of e-MBC sharing platform.
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