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Dopamine Modulation of Motivation and Motor Function in Major Depression & Inflammation — MOTIVADE  

Depressive Disorder, Major Clinical Trial

Official title:
Effects of Pharmacological Dopamine Modulation on Motivation and Motor Function in Major Depression Characterized by Low-grade Inflammation.

Clinical Trial Summary

A large body of evidence on depression heterogeneity point to an "immunometabolic" subtype characterized by the clustering of immunometabolic dysregulations with atypical behavioral symptoms related to energy homeostasis. Motivational and motor impairments reflected by symptoms of anhedonia and psychomotor retardation in major depression are closely related to alterations in energy homeostasis, are associated with increased inflammation, and may be a direct consequence of the impact of inflammatory cytokines on the dopamine system in the brain. In the proposed project, the investigators will examine the effect of dopamine stimulation on motivation and motor function in patients with major depression and healthy controls and the role of inflammation using a double-blind, randomized, placebo-controlled, cross-over design. If successful, this study would provide crucial evidence that pharmacologic strategies that increase dopamine may effectively treat inflammation-related symptoms of anhedonia and psychomotor retardation in major depression.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05909267
Study type Interventional
Source Charite University, Berlin, Germany
Contact Woo Ri Chae, MD MSc
Phone +49 30 450 517625
Email woo-ri.chae@charite.de
Status Recruiting
Phase N/A
Start date July 26, 2023
Completion date October 2025
View Details
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