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Pilot Study: Investigating Mood Changes After Slow-wave Enhancement — SWE  

Depression Clinical Trial

Official title:
Pilot Study: Investigating Mood Changes After Slow-wave Enhancement

Clinical Trial Summary

The aim of this pilot project proposal is to test the hypothesis that decreased sleep slow-wave activity (SWA) observed in individuals with major depressive disorder (MDD) is related to mood dysfunction, and that manipulating SWA may serve to improve mood by normalizing SWA regulation. The investigators propose to enhance SWA during nighttime sleep in a group of 20 antidepressant-free males and females age 25-50 with varying degrees of impairment in mood. Each participant will undergo one baseline night of sleep in the laboratory and then will sleep with the SmartSleep Headband nightly for two weeks in their own home. For one week, slow-wave sleep will be enhanced. On the alternate week, sleep will not be changed. Following the two weeks of sleeping with the device, participants will then spend another night in the sleep laboratory to assess changes in sleep. Mood will be assessed by self-report and clinician-administered scales following the baseline night of sleep, virtually after the first experimental week, and at the conclusion of the study.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05146427
Study type Interventional
Source University of Pennsylvania
Contact Jennifer Goldschmied, PhD
Phone 3473068202
Email jrgolds2@pennmedicine.upenn.edu
Status Not yet recruiting
Phase N/A
Start date January 1, 2025
Completion date October 1, 2025
View Details
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