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Reward Emotion Learning and Ketamine Study — RELAKS  

Depression Clinical Trial

Official title:
Reward Emotion Learning and Ketamine Study

Clinical Trial Summary

Ketamine's efficacy as an antidepressant is now well established yet the mechanisms underlying its antidepressant effect are yet to be fully described. Work in the animal literature and research in humans is suggestive of specific effects on anhedonia and memory reconsolidation. In this study the investigators will further explore the effects of ketamine on learning and memory as well as measuring the associated changes at neural level in a sample of healthy volunteers. Participants will be assigned to receive ketamine or placebo and complete a set of tasks which will allow the investigators to quantify the effect of ketamine on learning about reward and punishment and memory for learned reward associations 24 hours after ketamine infusion. This study will help the investigators to understand the basis of ketamine's antidepressant effects and aid the development of new treatments for depression.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04850911
Study type Interventional
Source University of Oxford
Contact Erdem Pulcu, PhD
Phone 01865613154
Email erdem.pulcu@psych.ox.ac.uk
Status Recruiting
Phase N/A
Start date August 25, 2021
Completion date May 2023
View Details
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