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The Associations Between Dietary Choline, Genetics and Anxiety/Depression

Depression Clinical Trial

Official title:
The Association Between Dietary Choline, Genetics and Anxiety/Depression

Clinical Trial Summary

The associations between dietary choline, genetics and anxiety/depression

Clinical Trial Description

Choline, previously considered to be a vitamin, is an essential nutrient involved in a plethora of biological pathways. Choline status is thought to be associated with depression and anxiety, however, the lack of evidence regarding the exact mechanism of its action warrants further investigation. This study aims to explore the associations between dietary choline and depression and anxiety in healthy individuals and how these may differ according to genetics, specifically Phosphatidylethanolamine N-Methyltransferase gene involved in endogenous and exogenous choline metabolism. Establishing these associations could reinforce the need for future intervention trials that could in turn establish causality and determine the mechanistic effects of dietary choline and the PEMT gene activity on depression/anxiety ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04036552
Study type Observational
Source St Mary's University College
Contact Leta Pilic, PhD
Phone 0208 240 4000
Email leta.pilic@stmarys.ac.uk
Status Not yet recruiting
Phase
Start date August 1, 2019
Completion date October 3, 2019
View Details
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