Mechanisms of Anxiety and Depression Study

Depression Clinical Trial

Official title:

Transdiagnostic Endophenotypes of Anxiety and Depression

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03135756
• Other study ID #: 15-003-H
• Status: Completed
• Start date: March 19, 2015
• Est. completion date: March 14, 2018

Study information

• Verified date: May 2018
• Source: Palo Alto University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Eligible participants will come in for three separate visits in which they will be interviewed, perform a variety of tasks, and undergo a non-invasive MRI scan. The investigators anticipate that (1) participants with anxiety and depression will likely perform differently than the healthy controls on cognitive tasks, (2) participants with anxiety and depression will likely show differences in brain functionality compared to the healthy controls, and (3) depression and anxiety likely share some underlying mechanisms.

Description:

In order to determine eligibility, a brief phone screen lasting approximately 15 minutes will be conducted. If participants are eligible, they will be asked to come in for three separate visits. During the first visit, participants will complete questionnaires as well as a structured interview with one of the study's staff members at Palo Alto University in Los Altos. During the second visit, participants would come to Palo Alto University in Los Altos and complete questionnaires as well as a testing session involving various tasks. During the third visit, participants would undergo a non-invasive brain scan in which participants would complete a task as well as various questionnaires at Stanford University in Stanford.

The investigators have flexible hours and can work around participants' schedules! To inquire more about participation, participants can either email the investigators at paloalto.study@gmail.com or call the investigators at (650) 417-2000 ext. 3642

Recruitment information / eligibility

• Status: Completed
• Enrollment: 63
• Est. completion date: March 14, 2018
• Est. primary completion date: March 14, 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 55 Years

Eligibility

Inclusion Criteria:

• Right-handed

• Healthy with no medical conditions OR have a history of anxiety and/or depression

• Ability to travel to both Palo Alto University and Stanford University

Related Conditions & MeSH terms

• Anxiety
• Anxiety Disorders
• Depression
• Depressive Disorder

Locations

Country	Name	City	State
United States	Palo Alto University	Los Altos	California
United States	Stanford University	Stanford	California

Sponsors (1)

Lead Sponsor	Collaborator
Palo Alto University

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Brain imaging	Non-invasive MRI brain scan to see function and structure of brain	Day 1
Primary	Assessment of symptoms and daily functioning	Structured Clinical Interview for DSM-IV, General demographic questionnaires, Penn State Worry Questionnaire, Intolerance of Uncertainty Questionnaire, The Positive and Negative Affect Schedule, Behavioral Inhibition Scale/Behavioral Activation Scale, The NEO Five-Factor Inventory, Mood and Anxiety Symptom Questionnaire, Alcohol Use Disorders Identification Test, Behavioral Regulation Index and Metacognition Index, General temperament Survey, Questionnaire of Mental Imagery, Rumination Reflection Questionnaire, Drug Abuse Screening Test, Childhood Trauma Questionnaire- Factor Structure, Emotion Regulation Questionnaire, Trait Meta-Mood Scale	Day 1
Primary	Cognitive assessment	Objective assessment of cognitive strengths and weaknesses via neuropsychological testing session	Day 1