Comparison of Depression Interventions After Acute Coronary Syndrome — CODIACS  

Depression Clinical Trial

Official title: Comparison of Depression Interventions After Acute Coronary Syndrome (CODIACS)

Status Completed

Clinical Trial Summary

Patients will be consented and screened within 2 to 6 months of the index ACS. Patients who have elevated depression (BDI>=15 or BDI>=10 assessed twice over two week period) and who continue to meet all of the trial's eligibility criteria will be consented. Through informed consent, both arms of the trial will be described with equipoise as to these approaches to postACS depression care. Patients who consent to randomization will be enrolled in the treatment trial.

The intervention phase will be 6 months, and hence the final outcome assessments will be performed approximately 9 months after the index ACS. Interim measures of depression will be obtained at 2 and 4 months post-enrollment. Major adverse cardiac events and all-cause mortality will also be ascertained at 6 months post-enrollment. Quality assurance by an independent medical event adjudication committee using prospective guidelines will be employed.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor)

Related Conditions & MeSH terms

• Acute Coronary Syndrome
• Depression
• Depressive Disorder
• Syndrome

• NCT number: NCT01032018
• Study type: Interventional
• Source: Columbia University
• Status: Completed
• Phase: Phase 1/Phase 2
• Start date: January 2010
• Completion date: July 2012