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Clinical Trial Summary

This study will investigate whether transcranial direct current stimulation (tDCS) enhances the effects of cognitive training in older adults with depression.


Clinical Trial Description

The purpose of this study is to determine whether the addition of active tDCS to computerized cognitive remediation (nCCR) enhances brain activity and cognitive functions in older adults with depression to a greater degree than nCCR with sham stimulation. The investigators will randomize 20 elderly depressed outpatients to either double-blinded active or sham bifrontal tDCS plus daily nCCR over 4-weeks. Multimodal MRI (focused on the cognitive control network; CCN) and psychiatric and neuropsychological evaluations will be obtained at baseline and following intervention completion. Long-term CCN cognitive effects will be explored 3-months post-intervention via cognitive assessments. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05400512
Study type Interventional
Source Vanderbilt University Medical Center
Contact Sarah M. Szymkowicz, PhD
Phone 615-875-0032
Email sarah.szymkowicz@vumc.org
Status Recruiting
Phase N/A
Start date February 8, 2023
Completion date September 2024

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