There are about 173942 clinical studies being (or have been) conducted in United States. The country of the clinical trial is determined by the location of where the clinical research is being studied. Most studies are often held in multiple locations & countries.
This was a retrospective cohort study to assess the treatment history, demographic characteristics, clinical characteristics, and early treatment patterns of patients who received brolucizumab for neovascular age-related macular degeneration using IRIS Registry.
The COVID-19 pandemic has caused significant morbidity and mortality across the world. Effective vaccines are now available but underutilized. In July 2021, Ascension Health implemented a mandate requiring all employees to obtain the COVID-19 vaccine by November 12th. In August 2021, the number of COVID-19 cases in the US increased rapidly, specifically in states with lower vaccination rates, many of which are served by Ascension Health facilities. In this study, we will evaluate a rapidly deployed health system initiative to use text messaging to nudge Ascension employees who have not yet been vaccinated to commit to a date and receive vaccination.
This study is designed to observe muscle oxygen saturation during intense video game using gridlock training with and without upper arm compression sleeves.
Sleep at altitude is often poor. The purpose of this study is to evaluate the effects of a single dose of the opioid antagonist, naltrexone, on sleep quality and periodic breathing after rapid ascent to ~3800m altitude.
Coaching is used in business and many other career paths to help the individual define and create their own goals and strategies for achieving those goals. In 2017 the investigators began to investigate the impact of coaching compared to non-coached peers in a randomized trial among non-internal medicine residency programs and internal medicine subspecialty fellowship to understand the impact of this program and its generalizability. Data from all these studies has suggested that coaching is effective in allowing trainees to understand their development over time, find meaning and purpose in their work, and identify their strengths and how to use these to overcome challenges and stressors. Additionally, there is a benefit to the coaches themselves, who can connect with other faculty coaches in a rewarding way, that provides faculty development in leadership development and positive psychology, and space to interact with a group of like-minded physicians. From the work the investigators have done with housestaff through the MGH Professional Development Coaching Program we have seen a tremendous interest from faculty members for access to similar services. Prior studies show improvement in faculty burnout and engagement at work through small-group sessions focused on reducing distress and promoting well-being. The investigators have also seen that while the training of novice coaches in positive psychology is sufficient to begin crucial conversations about drivers of well-being, the need for more in-depth coaching with certified coaches exists. The goal of this project is to expand coaching to MGH faculty members and provide more in-depth training for coaches through the International Federation of Coaching, through the Wellcoaches Coach Training Program. This is a unique approach to professional development within the field of medicine that has not yet been employed or studied. There was a recent publication of professional coaches hired outside of the field for faculty development, but there has been no training of medical colleagues with professional coaching skills. This has the potential to provide new data for the field and become a sustainable intervention for MGH in addressing ongoing professional development for our faculty and the burnout epidemic. Finally, this can serve as model for implementation in other institutions.
This is a randomized, placebo-controlled, crossover study of Trans Sodium Crocetinate (TSC) in healthy volunteers, age 18-40 (inclusive), exercising at altitude. The primary objective is to determine the effect of (TSC) on partial pressure of oxygen (PaO2) and maximal oxygen consumption (VO2 max); the secondary objective is to assess the effect of TSC on oxygen saturation (SpO2).
The overall goal of this study is to understand biological responses related to dupilumab treatment among severe asthma patients. Not all asthma is the same, and characteristics of asthma vary from person to person. The study will investigate whether the study drug can help to improve the health of participants lungs, boost immune response, as well as improve quality of life.
The purpose of this Phase I controlled human infection model (CHIM) study was to determine if oral administration of a good manufacturing practice (GMP) supply of Cryptosporidium parvum oocysts (ABO809) to healthy volunteers resulted in a Cryptosporidium infection and diarrheal illness. The study measured fecal oocysts (parasitological endpoint) as well as diarrhea and associated signs and symptoms (clinical endpoint).
The purpose of this study is to quantify the improvement of post- stroke individuals' ability to move their arms during and after robot assisted therapy. While researchers know that robot assisted therapies improve motor performance over the course of weeks, they do not know how motor performance is affected over the course of minutes or hours. A better understanding of how robot assisted therapies affect motor performance on short time scales may help us to prescribe more effective therapy doses to maximize motor recovery after neurological injury. The study will allow us to obtain a detailed understanding of the performance of the device as described above.
This first in human study is designed to evaluate the safety, tolerability, pharmacokinetics (PK), and food effect of GBT021601, a hemoglobin S (HbS) polymerization inhibitor, in healthy participants.