Comparison of Intravenous Lidocaine vs Ketamine in Colorectal Surgery

Status Recruiting

Clinical Trial Summary

Patients undergoing open colorectal surgery were randomly divided into two groups: Intravenous Lidocaine (IV-Lido) vs Intravenous Ketamine (IV-Keta). For the IV-Lido group, patients received a loading dose of Lidocaine than a continuous infusion over twenty-four hours. For the IV-Keta goup, patients received a loading dose of Ketamine than a continuous injection of Ketamine over twenty-four hours. Plasma concentrations of Interleukin-6(IL-6) were measured preoperatively before anesthetic induction and at twenty-four hour post operatively.

Clinical Trial Description

Patients undergoing open colorectal surgery with tumor resection were randomised prospectively into two groups: Intravenous Lidocaine (IV-Lido) vs Intravenous Ketamine (IV-Keta). For the IV-Lido group (n=25), patients received a loading dose of 1.5 mg/kg of Lidocaine than a continuous infusion of 1.5 mg/kg/h over twenty-four hours. For the IV-Keta goup(n=25), patients received a loading dose of 0.15mg/kg of Ketamine than a continuous injection of 0.15 mg/kg/h of Ketamine over twenty-four hours. For both groups, plasma concentrations of Interleukin-6(IL-6) were measured preoperatively before anesthetic induction and at twenty-four hour post operatively. Plasma IL-6 concentrations at each point were compared between the groups. ;

Study Design

Related Conditions & MeSH terms

Colorectal (Colon or Rectal) Cancer
Inflammation

Clinical Trial Details

NCT number	NCT06272461
Study type	Interventional
Source	University Tunis El Manar
Contact	BEN ALI MECHAAL, Professor
Phone	72100533
Email	mechaal_benali@yahoo.fr
Status	Recruiting
Phase	N/A
Start date	October 1, 2023
Completion date	June 30, 2024

View Details

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