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NCT ID: NCT05047835 Recruiting - Clinical trials for Cardiovascular Diseases

Comparison of Prone Position and Standard Electrocardiogram in COVID-19 Patients

Start date: September 10, 2021
Phase:
Study type: Observational

Prolonged prone position ventilation reduces the 30-day mortality in acute respiratory distress syndrome (ARDS) and in COVID-19 infection. A large number of patients with COVID-19 suffered from new-onset cardiac disease, therefore, ECG is crucial. However, there is limited data on the effects of prone position on the ECG in COVID-19 patients.

NCT ID: NCT05047601 Completed - COVID-19 Clinical Trials

A Study of a Potential Oral Treatment to Prevent COVID-19 in Adults Who Are Exposed to Household Member(s) With a Confirmed Symptomatic COVID-19 Infection

Start date: September 9, 2021
Phase: Phase 2/Phase 3
Study type: Interventional

The purpose of this clinical trial is to learn whether the study medicine prevent symptoms of COVID-19 in adults who have been exposed to household member(s) with a confirmed symptomatic COVID-19 infection. All participants in the study will receive treatment for COVID-19 as needed, based on their regular doctor's recommendation. Two-thirds of participants will also receive two study medicines (PF-07321332 and ritonavir) by mouth twice a day for either five or ten days. We will compare the experiences of people receiving the study medicines to those of the people who do not. This will help us determine if the study medicines are safe and effective

NCT ID: NCT05043389 Completed - Clinical trials for Obstructive Sleep Apnea

Impact of Myofuntional Therapy Program on Increasing Tongue Strength and Improving Sleep Apnea

Start date: January 1, 2021
Phase: N/A
Study type: Interventional

This Research studies for compare muscle strength among OSA patients who treat with myofunctional therapy program in Rajavithi hospital

NCT ID: NCT05042518 Completed - No Conditions Clinical Trials

Psychological Skill Training for Athletes

Start date: April 5, 2022
Phase: N/A
Study type: Interventional

The investigator will determine the effectiveness of psychological skill training on quantitative EEG in athletes before the competition.

NCT ID: NCT05042271 Recruiting - Autoimmune Diseases Clinical Trials

PK of Meropenem in Patients on Plasma Exchange

Start date: January 1, 2020
Phase:
Study type: Observational

Therapeutic plasma exchange (TPE) has been shown to be an important procedure for treatment of a variety of refractory immune complex disorders, such as Guillain-Barré syndrome and neuromyelitis optica. The intervention removes plasma, albumin, or some other substance. Meropenem is a broad-spectrum beta-lactam antimicrobial agent that is used for the treatment of serious nosocomial infections. Pathophysiological changes in patients on TPE can alter the pharmacokinetic (PK) patterns of coadministered antibiotics. This effect has an impact on the antimicrobial agents when paticipants are administered during the intervention. The aim of this study was to investigate the impact of TPE on meropenem PK.

NCT ID: NCT05041907 Recruiting - COVID-19 Clinical Trials

Finding Treatments for COVID-19: A Trial of Antiviral Pharmacodynamics in Early Symptomatic COVID-19 (PLATCOV)

PLATCOV
Start date: September 30, 2021
Phase: Phase 2
Study type: Interventional

The trial will develop and validate a platform for quantitative assessment of antiviral effects in low-risk patients with high viral burdens and uncomplicated COVID-19 to determine in-vivo antiviral activity. In this randomized open label, controlled, group sequential adaptive platform trial, we will assess the performance of three distinct types of intervention relative to control (no treatment): A: Small molecule drugs; B: Monoclonal antibodies PLATCOV study is supported by the Wellcome Trust Grant ref: 223195/Z/21/Z through the COVID-19 Therapeutics Accelerator.

NCT ID: NCT05037539 Completed - Pain, Breakthrough Clinical Trials

Efficacy of Injectable Fentanyl in Sublingual Route Versus Oral Morphine Syrup for Breakthrough Pain

Start date: June 15, 2021
Phase: Phase 1/Phase 2
Study type: Interventional

Randomized control trial that to comparison the efficacy of injectable fentanyl in sublingual route versus oral morphine syrup for breakthrough pain in gynecologic cancer patients with chronic cancer pain Primary outcome : to measure pain score after drug is given

NCT ID: NCT05036616 Recruiting - AKI Clinical Trials

Separation Versus Integrated Approach in Combining ECMO With CRRT

Start date: April 1, 2021
Phase:
Study type: Observational

This investigation aims to evaluate the filter life time of CRRT membrane and complication of combining ECMO and CRRT.

NCT ID: NCT05033522 Recruiting - Clinical trials for Hepatocellular Carcinoma

Immunotherapy for Advanced Liver Cancer

ALIVE
Start date: August 1, 2023
Phase: Phase 2/Phase 3
Study type: Interventional

This is a randomized, controlled multi-site, multi-national clinical trial conducted in Thailand and Malaysia for Asian adults (males or females), 18 years of age and older presenting with advanced HCC (BCLC stage C) including subjects with macrovascular involvement and/or extrahepatic spread (not eligible for TACE, surgery or locoregional treatment) with Child-Pugh stage A or B liver function. 150 subjects will be randomized 2:1 to AlloStim® immunotherapy vs Physician's Choice of Sorafenib, Lenvatinib or FOLFOX4.

NCT ID: NCT05032157 Completed - Clinical trials for Chronic Spontaneous Urticaria

A Phase 3 Study of Efficacy and Safety of Remibrutinib in the Treatment of CSU in Adults Inadequately Controlled by H1- Antihistamines

REMIX-2
Start date: December 1, 2021
Phase: Phase 3
Study type: Interventional

The purpose of this study is to establish the efficacy, safety, and tolerability of remibrutinib (LOU064) in adult participants suffering from chronic spontaneous urticaria (CSU) inadequately controlled by H1-antihistamines in comparison to placebo.