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NCT ID: NCT03876938 Recruiting - Clinical trials for Antiemetic for Highly Emetogenic Chemotherapy

Olanzapine Versus Aprepitant Based Antiemetic Regimen for High Emetic Chemotherapy

Start date: March 1, 2019
Phase: Phase 3
Study type: Interventional

Aprepitant and olanzapine have been recommended for emesis prevention from highly emetogenic chemotherapy. We hypothesized that olanzapine may lead to less nausea compared to aprepitant based on previous study. However, data of combination of olanzapine and ondansetron is scarce.

NCT ID: NCT03875235 Not yet recruiting - Clinical trials for Biliary Tract Neoplasms

A Global Phase III Study of Durvalumab or Placebo in Combination With Gemcitabine/Cisplatin in Patients With 1st Line Advanced Biliary Tract Cancer

TOPAZ-1
Start date: April 26, 2019
Phase: Phase 3
Study type: Interventional

A Global Phase III Study of durvalumab or placebo in combination with gemcitabine/cisplatin in patients with 1st line advanced biliary tract cancer.

NCT ID: NCT03875066 Completed - Clinical trials for Spinal Cord Injuries

Immediate Effects of Stepping Training Using External Feedback in Spinal Cord Injury Patients

Start date: May 10, 2018
Phase: N/A
Study type: Interventional

- Does stepping training with or without external feedback change functional ability of ambulatory patients with iSCI immediately after training? - Are there significant differences between the immediate effects of stepping training with or without external feedback in ambulatory patients with iSCI?

NCT ID: NCT03870711 Recruiting - Contraception Clinical Trials

10% Lidocaine Spray for Intrauterine Device Insertion

LidocaineIUD
Start date: August 1, 2018
Phase: Phase 4
Study type: Interventional

Intrauterine device (IUD) insertion is a procedure that can cause pain. Fear of pain during IUD insertion is a barrier to use of this method. Currently, there is no recommended standard method for reducing pain during this procedure. From Cochrane Database 2015, some lidocaine formulations, such as lidocaine spray, lidocaine gel and lidocaine paracervical injection, could reduce pain during IUD insertion, but there is limited data on effect of lidocaine spray on reducing pain during insertion of IUD.

NCT ID: NCT03869437 Not yet recruiting - Clinical trials for Bloodstream Infections

RCT Cefiderocol vs BAT for Treatment of Gram Negative BSI

GAMECHANGER
Start date: April 11, 2019
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine whether a new antibiotic, Cefiderocol which works against a wide variety of gram negative bacteria, is equally effective as the antibiotics that are currently used as current standard of care.

NCT ID: NCT03859362 Active, not recruiting - Clinical trials for Patients With Urosepis and Received Ertapenem for Treatment

Ertapenem in Patients With Urosepsis

Start date: January 2017
Phase: Phase 4
Study type: Interventional

Ertapenem, a broad-spectrum carbapenem antibiotic, has shown promising in vitro activity agenst ESBL-producing Enterobacteriacae. This agent was licensed in United State of America and Europe for several clinical use in complicated intraabdominal infections, complicated skin and skin-structure infections, acute pelvic infections, complicated urinary tract infections and community-acquired pneumonia. In common with other beta-lactams, ertapenem exhibits primarily time-dependent activity, and the percentage of the exposure time during which the free drug concentration remain above the MIC (%T>MIC) is the pharmacokinetic/pharmacodynamics (PK/PD) index that best correlates with efficacy. Pathophysiological changes in critically ill patients with severe infections resulting in altered PK patterns that may affect therapeutic plasma concentrations and achievement of PD have been found with several antimicrobial agents. The aim of the study was to determine the PK of ertapenem in patients with urosepsis.

NCT ID: NCT03858387 Enrolling by invitation - Clinical trials for Patients Who Received Imipenem or Meropenem or Piperacillin/Tazobactam or Sulbactam in ICU

Betalactams in ICU Patients

Start date: September 1, 2018
Phase: Phase 4
Study type: Interventional

Pharmacokinetics of betalactams in ICU patients

NCT ID: NCT03853798 Not yet recruiting - Clinical trials for Pyruvate Kinase Deficiency

Extension Study of AG-348 in Adult Participants With Pyruvate Kinase Deficiency Previously Enrolled in AG-348-006 or AG348-C-007

Start date: March 14, 2019
Phase: Phase 3
Study type: Interventional

This is a multicenter, open-label, extension study to evaluate the long-term safety, tolerability, and efficacy of treatment with AG-348 in participants who were previously enrolled in Study AG348-C-006 or Study AG348C-007.

NCT ID: NCT03849859 Not yet recruiting - Clinical trials for Plastic Stent Occlusion

Single Versus Multiple Plastic Stents in Malignant Distal Bile Duct Obstruction

Start date: May 1, 2019
Phase: N/A
Study type: Interventional

Endoscopic retrograde cholangiopancreatography (ERCP) with biliary stent placement is crucial for palliative treatment in patients with malignant bile duct obstruction who cannot perform surgery due to advanced diseases or associated comorbidities. Stent patency is challenge in ERCP. Self expanding metallic stents (SEMS) have a longer duration of patency and fewer of recurrence occlusion of stent when compared with plastic stent (PS). However, the cost of MS is more expensive than PS about 4 times. Therefore, many patients cannot afford the MS due to their economic status. Data regarding the efficacy and safety of multiple PS compared with single PS for the palliative treatment in unresectable malignant distal bile duct obstruction are limited.

NCT ID: NCT03849625 Recruiting - Aspirin Sensitivity Clinical Trials

Characteristics of Patients Diagnosed With NSAID Sensitivity in Thailand

Start date: July 2015
Phase:
Study type: Observational

Study clinical characteristics and phenotypes of patients diagnosed with NSAID sensitivity in Thailand