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NCT ID: NCT03739112 Recruiting - Clinical trials for Respiratory Tract Infections

Efficacy of a Plant-derived Quadrivalent VLP Vaccine in the Elderly

Start date: September 18, 2018
Phase: Phase 3
Study type: Interventional

This Phase 3 study is intended to assess the efficacy of the Quadrivalent VLP Influenza Vaccine during the 2018-2019 influenza season in elderly adults 65 years of age and older. One dose of Quadrivalent Virus-Like Particles (VLP) Influenza Vaccine (30 μg/strain) or of Comparator (15 ug/strain) placebo will be administered to approximately 12,120 subjects.

NCT ID: NCT03731559 Not yet recruiting - HIV/TB Coinfection Clinical Trials

Efficacy, Safety and Pharmacokinetics of DTG With RIF

Start date: December 1, 2018
Phase: Phase 2
Study type: Interventional

The overall aim of the project is to evaluate optimal DTG dose for the combined treatment of TB and HIV infections with RIF based anti-TB therapy. This Stage II trial will determine precisely the PK parameters of DTG in combination with RIF regimen in Thai HIV/TB co-infected patients. After the optimal dose of DTG has been found, it will be further tested in a larger Stage III trial to assess its safety, tolerability and efficacy when used with RIF based regimen.

NCT ID: NCT03730311 Not yet recruiting - HIV Infections Clinical Trials

Phase Ib Study of Safety, Tolerability and Pharmacokinetics of Elpida Once Weekly in Healthy Volunteers

Start date: December 2018
Phase: Phase 1
Study type: Interventional

A randomized, placebo-controlled, once weekly dose for four weeks, double blind study in Healthy HIV-Uninfected Volunteers (6 active; 2 placebo) with 40 mg and 80 mg in parallel followed by 120 mg after DSMB approval.

NCT ID: NCT03729102 Not yet recruiting - Rabies Clinical Trials

Immunological Tolerance After Frequent Rabies Booster Vaccinations

Start date: June 2019
Phase: N/A
Study type: Interventional

To study immunological tolerance effect after frequent rabies booster vaccination

NCT ID: NCT03727152 Not yet recruiting - HIV Clinical Trials

Switching From Protease Inhibitor/Ritonavir to Generic Single Tablet Regimen of Tenofovir Alafenamide/Emtricitibine/Dolutegravir

Start date: January 1, 2019
Phase: Phase 3
Study type: Interventional

This is a phase III, multicenter, open-label, single-arm study of 190 virologically suppressed HIV-infected adults

NCT ID: NCT03716453 Recruiting - Postoperative Pain Clinical Trials

Intraoperative Fentanyl Consumption Guided by Analgesia Nociception Index

Start date: October 1, 2018
Phase: N/A
Study type: Interventional

Balanced anesthesia needs optimization of hypnotic, relaxant, and narcotic. Administration of hypnotic drugs can be monitored by bispectral index score (BIS), while the dosage of muscle relaxants can be guided by train-of four (TOF). However, administration of narcotics lacks objective monitor. Overdosage of narcotic may lead to delayed awakening, while underdosage may lead to high degree of postoperative pain. Recently, there is a monitor, Analgesic Nociceptive Index (ANI) monitor, designed to guide the administration of narcotics. There are many descriptive studies supporting the correlation of ANI score and pain score but there are still very few randomized control studies which report the efficacy of ANI in clinical practice.

NCT ID: NCT03715790 Not yet recruiting - Clinical trials for Acute Myocardial Infarction

Improve SCA Bridge Study

Start date: November 2018
Phase:
Study type: Observational

The purpose of the Improve SCA Bridge study is to characterize the care pathway flow of post‐acute myocardial infarction (MI) patients as a result of standard assessments of left ventricular ejection fraction (LVEF) in the acute phase (≤14 days post‐ acute MI) and chronic phase (≥40‐90 days post‐acute MI).

NCT ID: NCT03703869 Recruiting - Diabetes Clinical Trials

Twelve -Month Study Observing How Insulin-naïve Patients With Type 2 Diabetes Mellitus Manage Diabetes Using Toujeo® After Oral Antidiabetic Drug Failure, the Side Effect of Toujeo®, and The Cost.

ATOS
Start date: March 6, 2018
Phase:
Study type: Observational

Primary Objective: Assess effectiveness of insulin glargine (U300) in achieving glycemic goal measured by hemoglobin A1c (HbA1c). Secondary Objectives: - Assess effectiveness in achieving glycemic goal measured by HbA1c; - Assess effectiveness on change in HbA1c, fasting plasma glucose (FPG) and self-monitored plasma glucose (SMPG) ; - Assess requirement for intensification of therapy by additional antidiabetics. - Assess incidence of hypoglycemia; - Assess other safety endpoints: adverse events (AEs), serious adverse events (SAEs); - Assess change in body weight.

NCT ID: NCT03700944 Completed - Allergic Rhinitis Clinical Trials

Yoga Training in Allergic Rhinitis Patients

Start date: January 1, 2018
Phase: N/A
Study type: Interventional

The purpose of this study was to investigate effects of yoga training on rhinitis symptoms and cytokines in allergic rhinitis patients. Twenty-seven allergic rhinitis patients, aged 18-45 year old, were randomized into 2 groups: control group (CON; n=14) and yoga group (YOG; n=13). The control group had normal life and the yoga group was required to complete protocol with yoga training for a period of 8 weeks, 60 minutes, 3 times a week. Physiological variables, lung function variables, allergic rhinitis symptoms variables, and cytokines level in nasal secretion variables were analyzed during pre-test and post-test. The dependent variables between pre-test and post-test were analyzed by a paired t-test. The dependent variables between groups were analyzed by independent t-test. One way repeated measures ANOVA was used to compare the variables among pre-test, after 4 weeks, and after 8 weeks. Differences were considered to be significant at p < 0.05.

NCT ID: NCT03698799 Recruiting - Clinical trials for Perioperative/Postoperative Complications

Adherence to LPV in SICU and Associated Clinical Outcomes

Start date: April 9, 2018
Phase:
Study type: Observational

Lung Protective Ventilation strategy (LPV) with low tidal volume and adequate positive end-expiratory pressure is recommended for not only patients with acute respiratory distress syndrome (ARDS) but also those without ARDS too. From previous studies, adherence to LPV strategy reported is only 40% and data is limited in surgical patients. The investigators aim to describe ventilation management and find out the adherence rate to LPV strategy applied to surgical patients admitted to the surgical intensive care unit (SICU) and their associated outcomes.