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NCT ID: NCT03805620 Recruiting - Clinical trials for Mild Cognitive Impairment

Effects of Combined Physical-cognitive Training on Cognitive Function in MCI

Start date: January 2019
Phase: N/A
Study type: Interventional

The present study aims to investigate the effects of combined physical-cognitive training on cognitive function as well as peripheral BDNF level and mitochondrial function of individuals with MCI. It is hypothesized that: 1) the combined physical-cognitive training program will be superior to the physical and cognitive training program alone; and 2) the degree of cognitive improvement will be positively correlated with the improvement of plasma BDNF and mitochondrial function.

NCT ID: NCT03801889 Not yet recruiting - Iron Overload Clinical Trials

SP-420 in Subjects With Transfusion-dependent Beta-Thalassemia or Other Rare Anemias

Start date: May 2019
Phase: Phase 2
Study type: Interventional

The purpose of this study is to test the safety and tolerability of SP-420 and it's efficacy in terms of lowering iron in subjects with Beta-thalassemia or other rare anemias who need regular blood transfusions.

NCT ID: NCT03800979 Not yet recruiting - Alopecia Areata Clinical Trials

Effectiveness and Safety of Tofacitinib in Patients With Extensive and Recalcitrant Alopecia Areata

Start date: January 12, 2019
Phase: Phase 4
Study type: Interventional

The objective of this study is to assess the safety and efficacy of Tofacitinib in treating patients with extensive and recalcitrant Alopecia Areata (AA), along with to evaluate the economic impact of the patients that may be from changing in their quality of life. There are patients with severe AA who may have little or no improvement from the treatment by diphenylcyclopropenone (DPCP) or topical steroid with minoxidil but instead having positive response from the treatment with Janus kinase(JAK) inhibitor such as Tofacitinib or Ruxolitinib. For the best of my knowledge, there was no previous study in using Tofacitinib to treat severe AA before in Thailand.

NCT ID: NCT03789019 Completed - Clinical trials for Metastatic Breast Cancer

BP-C1 Monotherapy in Patients With Metastatic Breast Cancer: Estimation of Optimal Duration of Treatment

Start date: February 22, 2013
Phase: Phase 2
Study type: Interventional

The purpose of this study is to establish an optimal treatment duration and tolerable cumulative dose for BP-C1 in the treatment of metastatic breast cancer patients who had previously undergone at least three lines of chemotherapy.

NCT ID: NCT03788642 Not yet recruiting - Diabetic Foot Ulcer Clinical Trials

Low-level Laser Therapy for the Treatment of Diabetic Foot Ulcer

Start date: January 15, 2019
Phase: N/A
Study type: Interventional

The study evaluates the efficacy of Low-level laser therapy on ulcer healing in patients with diabetic foot ulcer. Half the patients are randomized to receive Low-level laser therapy and a half to recieve the placebo (LED).

NCT ID: NCT03787979 Not yet recruiting - Back Pain Clinical Trials

Relative Stiffness of Lumbar Spine and Hamstrings Muscle Stretching

Start date: December 24, 2018
Phase: N/A
Study type: Interventional

The purpose of this study is to investigate the effect of lumbopelvic stabilization on hamstrings muscle stretching in individuals with history of low back pain suspected to have a clinical lumbar instability.

NCT ID: NCT03786627 Not yet recruiting - Instability; Back Clinical Trials

Neuromuscular Electrical Stimulation and Motor Control

Start date: January 1, 2019
Phase: N/A
Study type: Interventional

Phase I, this study aims to:- 1. Establish intra- and inter-rater reliability and minimal detectable change of ultrasound imaging measurement 2. Determine appropriate mode and dose for neuromuscular electrical stimulation on lumbar multifidus muscle 3. Determine feasibility of proposed protocol and physical therapy intervention Phase II, this study aims to:- 1. Determine the difference lumbar multifidus muscle activation based on arthrogenic muscle inhibition model between individuals with and without impaired lumbopelvic control 2. Determine the effect of combined neuromuscular electrical stimulation and motor control training in individual with impaired lumbopelvic control

NCT ID: NCT03785106 Not yet recruiting - Clinical trials for HIV-infected Participants With Latent TB Infection in High TB Burden Country

Tuberculosis Preventive Therapy Among Latent Tuberculosis Infection in HIV-infected Individuals

Start date: March 2019
Phase: Phase 3
Study type: Interventional

The investigators want to know if ultra-short, effective treatment for latent tuberculosis (TB) infection (LTBI) could dramatically reduce the global incidence of active TB or not. The investigators hypothesize that short-course (4-week) daily isoniazid/rifapentine (INH/RPT) (1HP) is not inferior to standard -course (12 weeks) INH/RPT weekly regimen (3HP) for the prevention of TB in human immunodeficiency virus (HIV)-infected individuals.

NCT ID: NCT03784521 Recruiting - SIRS Clinical Trials

Efficacy of Intravenous In-line Filter in Patient Undergoing Cardiac Surgery

Start date: January 3, 2019
Phase: N/A
Study type: Interventional

The aim of this study is to demonstrated efficacy of in-line filtration to reduce systemic inflammatory response syndrome (SIRS) ,specific organ dysfunction and complications in adult cardiac surgery. 486 patients undergoing cardiac surgery for acquired heart disease are 1:1 randomized into in-line filtration (study group) and non-filtration (control group). The incidence of SIRS, complications, daily SOFA (sequential organ failure assessment) score are compared between groups.

NCT ID: NCT03778957 Recruiting - Clinical trials for Hepatocellular Carcinoma

A Global Study to Evaluate Transarterial Chemoembolization (TACE) in Combination With Durvalumab and Bevacizumab Therapy in Patients With Locoregional Hepatocellular Carcinoma

EMERALD-1
Start date: November 30, 2018
Phase: Phase 3
Study type: Interventional

A global study to evaluate transarterial chemoembolization (TACE) in combination with durvalumab and bevacizumab therapy in patients with locoregional hepatocellular carcinoma