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NCT ID: NCT00863681 Completed - Clinical trials for Hypertension, Pulmonary

BAY63-2521:Long-term Extension Study in Patients With Pulmonary Arterial Hypertension

PATENT-2
Start date: March 12, 2009
Phase: Phase 3
Study type: Interventional

Patients who have completed the 12 weeks treatment of the PATENT-1 trial (study number 12934) will be asked to participate in this long term extension study with BAY63-2521.

NCT ID: NCT00862667 Completed - Healthy Clinical Trials

A Study To Estimate The Time Course Of PF-00241939 Concentration In The Blood Following Dosing By Oral Inhalation From Dry Powder Inhalers.

B0871002
Start date: May 2009
Phase: Phase 1
Study type: Interventional

The purpose of this study is to investigate the time course of PF-00241939 concentration in the blood following dosing by oral inhalation from dry powder inhalers.

NCT ID: NCT00860496 Completed - Healthy Volunteers Clinical Trials

A Phase I Open-Label Study of the Effects of Tacrolimus and Cyclosporine on CP-690,555 in Healthy Volunteers

Start date: June 2009
Phase: Phase 1
Study type: Interventional

A new immunosuppressive drug, based on the inhibition of important enzymes in the immune system, called JAK, is being developed by Pfizer to prevent transplant rejection. Since many treatments for transplant rejection may be administered together, this research study will analyze the effects of common transplant rejection therapies, Tacrolimus and Cyclosporine, on the JAK inhibitor, CP-690,550.

NCT ID: NCT00858637 Completed - Clinical trials for Chronic Kidney Disease

Efficacy and Safety Study of MCI-196 Versus Simvastatin for Dyslipidaemia in Chronic Kidney Disease (CKD) Subjects on Dialysis

Start date: March 2009
Phase: Phase 3
Study type: Interventional

The primary objective of this study is to demonstrate the superiority of MCI-196 over placebo and non-inferiority with simvastatin in reducing serum low-density lipoprotein (LDL)-cholesterol in subjects with chronic kidney disease Stage V on dialysis. This study incorporates a Washout Period and two treatment periods - an active comparison phase and a placebo-controlled withdrawal phase.

NCT ID: NCT00856349 Completed - Clinical trials for Cardiovascular Disease

Medtronic Shock-Less Study on Physician Utilization of Shock Reduction Programming

Start date: April 2009
Phase: N/A
Study type: Observational

The purpose of this clinical trial is to determine whether periodic therapy programming reports illustrating physician usage of shock reduction programming can increase utilization of recommended programming guidelines for defibrillators.

NCT ID: NCT00856284 Completed - Clinical trials for Type 2 Diabetes Mellitus

Efficacy and Safety of Alogliptin Plus Metformin Compared to Glipizide Plus Metformin in Patients With Type 2 Diabetes Mellitus

ENDURE
Start date: March 2009
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine the safety and effectiveness of adding alogliptin, once daily (QD), compared to glipizide with metformin in diabetic patients.

NCT ID: NCT00855530 Completed - Clinical trials for Major Depressive Disorders

Long Term Safety and Tolerability of SR58611 in Patients With Major Depressive Disorder

Start date: September 2005
Phase: Phase 3
Study type: Interventional

Primary objective: - To evaluate the long-term safety and tolerability of SR58611A (amibegron) patients with major depressive disorder (MDD). Secondary objective: - To determine plasma concentrations of SR58878 (the active metabolite of SR58611A), for pharmacokinetic population analyses, to evaluate the quality of life (QoL) in patients with MDD, and to evaluate the efficacy of amibegron in patients with MDD.

NCT ID: NCT00855218 Completed - Clinical trials for Carcinoma, Hepatocellular

A Phase II Randomized, Double-blind, Placebo-controlled Study of Sorafenib or Placebo in Combination With Transarterial Chemoembolization (TACE) Performed With DC Bead and Doxorubicin for Intermediate Stage Hepatocellular Carcinoma (HCC).

Start date: March 2009
Phase: Phase 2
Study type: Interventional

This study will look at whether our drug (sorafenib) in combination with chemotherapy delivered directly into your tumor using beads (DC Bead) will slow the progression of the disease. The beads used with the chemotherapy will slowly release the chemotherapy reducing the adverse effects that normally occur with chemotherapy.

NCT ID: NCT00850031 Completed - Presbyopia Clinical Trials

Safety and Effectiveness Study of the AcuFocus Corneal Inlay ACI 7000PDT in Presbyopes

ACI
Start date: January 2009
Phase: N/A
Study type: Interventional

The purpose of this study is to determine if the AcuFocus Corneal Inlay ACI 7000PDT will provide an effective method for the correction of presbyopia in patients who have normal distance vision but need a correction such as glasses or contact lenses to see clearly at near.

NCT ID: NCT00841672 Completed - Clinical trials for Moderate to Severe Hypertension

Efficacy and Safety of the Combination of Aliskiren (300 mg) and Amlodipine (10 mg) Compared to Amlodipine (10 mg) Monotherapy in Patients With Moderate to Severe Hypertension

Start date: January 2009
Phase: Phase 3
Study type: Interventional

This study will compare the blood pressure (BP) lowering effect of the combination of aliskiren/amlodipine 300/10 mg versus amlodipine 10 mg monotherapy in patients with moderate to severe hypertension by testing the hypothesis that the combination of aliskiren/amlodipine produces a superior reduction from baseline in mean sitting systolic blood pressure (msSBP) after 8 weeks of treatment.