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NCT ID: NCT02299817 Active, not recruiting - Osteolysis Clinical Trials

Denosumab for Treating Periprosthetic Osteolysis.

Start date: August 2015
Phase: Phase 2
Study type: Interventional

The main objective is to study the efficacy of denosumab in reducing wear-induced osteolysis around uncemented acetabular implants used in total hip arthroplasty. Patients included in the study will receive the same dose of 60 mg denosumab or placebo (1 ml solution) for a total of 6 doses with start on day one and every 6 months with last treatment at 30 months. The primary endpoint will be the change in volume of the osteolytic lesion over 3 years measured (measured with 3D-CT in cm³).

NCT ID: NCT02299596 Active, not recruiting - Colorectal Cancer Clinical Trials

Physical Activity in Relation to Surgical Procedures

Start date: January 2015
Phase: N/A
Study type: Interventional

This study will compare the outcome after surgery between a group of patients that receives instructions for prehabilitation training and one group that received standard treatment.

NCT ID: NCT02299089 Completed - Clinical trials for Neuroendocrine Tumors

Phase II Study of Subcutaneous Inj. Depot of Octreotide in Patients With Acromegaly and Neuroendocrine Tumours (NETs)

Start date: January 2015
Phase: Phase 2
Study type: Interventional

This is a Phase II, open-label multicentre, randomised study to assess the PK, PD, efficacy, and safety of two dosing regimens of CAM2029 in adult patients with acromegaly or a functional, well-differentiated NET, with carcinoid symptoms.

NCT ID: NCT02297971 Completed - PCI Clinical Trials

Assessment of Coagulation and Thrombocyte Function After Termination of Ticagrelor

BRILIQUE
Start date: September 2013
Phase: N/A
Study type: Observational

When ticagrelor should be discontinued prior to elective surgery is unclear. The risks of bleeding when it is continued peri-operatively have to be weighed against the risk of coronary artery thrombosis when stopped. This study aims to assess coagulation and thrombocyte function every other day in patients who are taking ticagrelor after coronary artery stents and discontinue therapy at the end of one year.

NCT ID: NCT02297516 Completed - Aesthetics Clinical Trials

Safety and Efficacy of Azzalure/Dysport, Restylane/Emervel Filler and Restylane Skinbooster Treatment

Start date: November 2014
Phase: Phase 4
Study type: Interventional

The efficacy and safety, as well as subject satisfaction will be evaluated after single treatment with Azzalure/Dysport alone or Restylane/Emervel filler alone followed by repeated combined treatment with Azzalure/Dysport, Restylane/Emervel filler and Restylane Skinbooster. Subjects will be followed for up to 18 months after initial treatment.

NCT ID: NCT02297503 Completed - Clinical trials for Facial Aesthetic Treatment

Safety and Efficacy of Treatment With Azzalure, Restylane/Emervel Filler and Restylane Skinbooster

Start date: November 2014
Phase: Phase 4
Study type: Interventional

The efficacy and safety, as well as subject satisfaction will be evaluated after single treatment with Azzalure alone or Restylane/Emervel filler alone followed by repeated combined treatment with Azzalure, Restylane/Emervel filler and Restylane Skinbooster. Subjects will be followed for up to 18 months after initial treatment.

NCT ID: NCT02296424 Completed - Clinical trials for Systemic Juvenile Idiopathic Arthritis (SJIA)

ß-SPECIFIC 4 Patients: Study of Pediatric EffiCacy and Safety wIth FIrst-line Use of Canakinumab

ß-SPECIFIC 4
Start date: November 17, 2014
Phase: Phase 3
Study type: Interventional

The purpose of this study was to evaluate the efficacy observed with canakinumab dose reduction in a subgroup of patients in the extension study CACZ885G2301E1.

NCT ID: NCT02296138 Completed - Clinical trials for Pulmonary Disease, Chronic Obstructive

Comparing the Efficacy of Tiotropium + Olodaterol (5/5 µg) Fixed Dose Combination (FDC) Over Tiotropium 5µg in Reducing Moderate to Severe Exacerbations in Patients With Severe to Very Severe Chronic Obstructive Pulmonary Disease.

Start date: January 13, 2015
Phase: Phase 3
Study type: Interventional

The overall objective is to assess the effect of once daily tiotropium + olodaterol fixed dose combination compared to 5 µg tiotropium (both delivered with the Respimat® inhaler) on moderate to severe COPD exacerbation in patients with severe to very severe COPD.

NCT ID: NCT02296125 Active, not recruiting - Clinical trials for Locally Advanced or Metastatic EGFR Sensitising Mutation Positive Non Small Cell Lung Cancer

AZD9291 Versus Gefitinib or Erlotinib in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer

FLAURA
Start date: December 3, 2014
Phase: Phase 3
Study type: Interventional

To assess the efficacy and safety of AZD9291 versus a standard of care epidermal growth factor receptor tyrosine kinase inhibitor in patients with locally advanced or Metastatic Non Small Cell Lung Cancer

NCT ID: NCT02295579 Completed - Bacterial Vaginosis Clinical Trials

Will Lactobacillus Increase Cure Rate After Treatment of Bacterial Vaginosis and Chronic Vulvovaginal Candida

Start date: June 2014
Phase:
Study type: Observational [Patient Registry]

From the earlier studies the investigators have treated women with bacterial vaginosis and cronic vulvovaginal candida. The investigators have then treated them with laktobacilli 10 days for 2 month. The investigators will continue to follow them and investigate if treatment with lactobacilli every week for 6 month will increase cure rate.