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NCT ID: NCT00863655 Completed - Breast Cancer Clinical Trials

Everolimus in Combination With Exemestane in the Treatment of Postmenopausal Women With Estrogen Receptor Positive Locally Advanced or Metastatic Breast Cancer Who Are Refractory to Letrozole or Anastrozole

BOLERO-2
Start date: June 2009
Phase: Phase 3
Study type: Interventional

There are no treatments specifically approved after recurrence or progression on a non steroidal aromatase inhibitors (NSAI). In light of the need for new treatment options for postmenopausal women after failure of prior NSAI therapy, the purpose of this Phase III study is to compare efficacy and safety of a treatment with exemestane + everolimus to exemestane + placebo in postmenopausal women with estrogen receptor positive locally advanced or metastatic breast cancer refractory to NSAI.

NCT ID: NCT00863161 Completed - Reflux Clinical Trials

Renal Impairment Study

Start date: March 2009
Phase: Phase 1
Study type: Interventional

The purpose of this study is to see how quickly AZD3355 is taken up in to the blood and leaves the blood in people with normal kidney function or with different degrees of reduced kidney function.

NCT ID: NCT00861809 Completed - Gastroparesis Clinical Trials

The Effect of Single Doses of the Motilin Receptor Agonist GSK962040 in Type I Diabetic Patients With Gastroparesis

Start date: June 2009
Phase: Phase 2
Study type: Interventional

The purpose of this study is to assess the pharmacodynamic effects (gastric emptying), safety, tolerability, and pharmacokinetics of single doses of GSK962040 in Type 1 diabetic patients with gastroparesis.

NCT ID: NCT00861120 Completed - Clinical trials for Epithelial Ovarian Cancer

Panitumumab and Pegylated Liposomal Doxorubicin for Platinum-Resistant Epithelial Ovarian Cancer With KRAS Wild-type

PaLiDo
Start date: April 2009
Phase: Phase 2
Study type: Interventional

The purpose of this study is to investigate the response rate in platinum-resistant, KRAS wild-type, ovarian cancer patients who are treated with pegylated liposomal doxorubicin (Caelyx®) in combination with biological treatment panitumumab (Vectibix®).

NCT ID: NCT00860821 Completed - Healthy Clinical Trials

A Methodology Study in Healthy Subjects to Evaluate the Effect of AZD8309 After Nasal Administration of Lipopolysaccharide (LPS)

Start date: March 2009
Phase: N/A
Study type: Interventional

The purpose of this methodology study is to evaluate the effect of AZD8309 on cells and inflammatory biomarkers in nasal lavage and blood after nasal challenge with lipopolysaccharide (LPS)

NCT ID: NCT00860301 Completed - Infantile Colic Clinical Trials

Acupuncture in Infantile Colic

Start date: December 2006
Phase: N/A
Study type: Interventional

The purpose of this study is to investigate whether acupuncture influences: - the rate of infants who still fulfil the colic criterion after three intervention weeks - the time when the infants are crying, fussing or have intense bouts of colicky symptoms

NCT ID: NCT00860080 Completed - Clinical trials for Post-surgery Adhesion Formation

Safety Study Investigating Local Tolerability and Pharmacokinetics of PXL01 in Healthy Volunteers

Start date: March 2009
Phase: Phase 1
Study type: Interventional

The main purpose of this study is to determine whether three different single doses of PXL01 are safe and well tolerated by healthy volunteers. The pharmacokinetic properties of PXL01 (same doses) will also be investigated.

NCT ID: NCT00859729 Completed - Prostate Cancer Clinical Trials

Dose Finding Study of a DNA Vaccine Delivered With Intradermal Electroporation in Patients With Prostate Cancer

Start date: December 2008
Phase: Phase 1/Phase 2
Study type: Interventional

This study will assess the feasibility and safety of vaccination with increasing doses of xenogenic DNA administered intradermally in combination with electroporation in patients with relapse of prostate cancer. The DNA encodes prostate specific antigen (PSA) from Rhesus Macaque (Macaca mulatta), a protein that is 89% homologous to human PSA. The study will also assess the safety and functionality of the DERMA VAX™ (Cyto Pulse Sciences) DNA vaccine delivery system.

NCT ID: NCT00859352 Completed - Clinical trials for Healthy Male Volunteer

AZD1981 Midazolam CYP4503A Induction Study

Start date: March 2009
Phase: Phase 1
Study type: Interventional

The primary objective of the study is to investigate if the exposure of midazolam is clinically significantly changed by 14 days of exposure to AZD1981 through possible enzyme induction of CYP3A.

NCT ID: NCT00858871 Completed - Clinical trials for Hepato Cellular Carcinoma (HCC)

First Line Hepato Cellular Carcinoma (HCC)

BRISK FL
Start date: May 2009
Phase: Phase 3
Study type: Interventional

The purpose of this study is to compare the overall survival of brivanib versus sorafenib in subjects with advanced HCC who have not received prior systemic therapy.