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NCT ID: NCT01853826 Completed - Clinical trials for Carcinoma, Non-Small-Cell Lung

An Open Label Trial of Afatinib (Giotrif) in Treatment-naive (1st Line) or Chemotherapy Pre-treated Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC) Harboring EGFR Mutation(s)

Start date: July 17, 2013
Phase: Phase 3
Study type: Interventional

To evaluate the safety and tolerability of afatinib (Giotrif) in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) harboring EGFR mutation(s) and have never been treated with an EGFR-TKI

NCT ID: NCT01851707 Completed - Clinical trials for Rheumatoid Arthritis

A Double-Blind Study Evaluating Duvelisib in Subjects With Moderate to Severe Rheumatoid Arthritis and an Inadequate Response to Methotrexate Alone

ASPIRA
Start date: April 2013
Phase: Phase 2
Study type: Interventional

The purpose of this study is to investigate the safety and efficacy of multiple dose levels of the investigational product (study drug), IPI-145, in combination with methotrexate compared to methotrexate alone in subjects with active moderate-to-severe Rheumatoid Arthritis.

NCT ID: NCT01850524 Completed - Multiple Myeloma Clinical Trials

IXAZOMIB Plus Lenalidomide and Dexamethasone Versus Placebo Plus Lenalidomide and Dexamethasone in Adult Patients With Newly Diagnosed Multiple Myeloma

Start date: April 29, 2013
Phase: Phase 3
Study type: Interventional

The purpose of this study is to provide continued access to ixazomib and/or lenalidomide to participants who are continuing to have clinical benefit and to continue collecting relevant safety data to monitor safety in participants with Newly Diagnosed Multiple Myeloma (NDMM) who are not eligible for stem cell transplant.

NCT ID: NCT01850446 Completed - Influenza Clinical Trials

Comparative Clinical Trial of Efficacy and Safety of Ergoferon Versus Oseltamivir in Treatment of Influenza

Start date: February 20, 2015
Phase: Phase 4
Study type: Interventional

The purpose of this study is: - to assess the efficacy of Ergoferon in treatment of influenza; - to assess the safety of Ergoferon in treatment of influenza; - to compare the efficacy of Ergoferon and Oseltamivir for treatment of influenza.

NCT ID: NCT01850030 Completed - Female Infertility Clinical Trials

A Multicenter Study Comparing the Efficacy, Safety and Tolerability of Oral Dydrogesterone 30 mg Daily Versus Intravaginal Micronized Progesterone Capsules 600 mg Daily for Luteal Support in In-Vitro Fertilization

Lotus I
Start date: August 2013
Phase: Phase 3
Study type: Interventional

Female inability to conceive a child. The purpose of this randomized, two-arm and double blind, double dummy study is to demonstrate that the treatment of a daily dose of 3x10mg dydrogesterone orally is as effective and safe as the daily dose of 3x200 mg micronized progesterone capsules administered intravaginally for the luteal support in patients undergoing IVF. The treatment will start on the day of oocyte retrieval and continue until pregnancy is negative or until week 12 gestation.Patients will be followed after treatment until 30 days after delivery to record any safety and tolerability data of the patient and their newborn(s).

NCT ID: NCT01846611 Completed - Ovarian Neoplasms Clinical Trials

A Study Comparing the Combination of Trabectedin (YONDELIS) and DOXIL/CAELYX With DOXIL/CAELYX for the Treatment of Advanced-Relapsed Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

Start date: October 16, 2013
Phase: Phase 3
Study type: Interventional

The purpose of this study is to assess the efficacy and safety of trabectedin+DOXIL as a third-line chemotherapy regimen (treatment) in patients with platinum-sensitive advanced-relapsed epithelial ovarian, primary peritoneal, or fallopian tube cancer who received 2 previous lines of platinum-based chemotherapy.

NCT ID: NCT01846299 Completed - Macular Edema (ME) Clinical Trials

To Assess the Efficacy and Safety of Intravitreal Ranibizumab in People With Vision Loss Due to Macular Edema

Start date: October 2013
Phase: Phase 3
Study type: Interventional

To evaluate the efficacy and safety of 0.5 mg in adult patients with visual impairment due to macular edema (ME).

NCT ID: NCT01845350 Completed - Ischemic Stroke Clinical Trials

Safety of Autologous M2 Macrophage in Treatment of Non-Acute Stroke Patients

Start date: October 2012
Phase: Phase 1
Study type: Interventional

The purpose of this study is to determine whether M2 macrophages are safe and feasible in the treatment of non-acute stroke patients

NCT ID: NCT01844856 Completed - Clinical trials for Complicated Intra-abdominal Infections

Efficacy and Safety Study of Eravacycline Compared With Ertapenem in Complicated Intra-abdominal Infections

IGNITE1
Start date: August 2013
Phase: Phase 3
Study type: Interventional

This is a Phase 3, randomized, double-blind, double-dummy, multicenter, prospective study to assess the efficacy, safety, and pharmacokinetics of eravacycline compared with ertapenem in the treatment of adult complicated intra-abdominal infections (cIAI).

NCT ID: NCT01844765 Completed - Clinical trials for Philadelphia Positive (Ph+) Chronic Myelogenous Leukemia

Open Label, Phase II Study to Evaluate Efficacy and Safety of Oral Nilotinib in Philadelphia Positive (Ph+) Chronic Myelogenous Leukemia (CML) Pediatric Patients.

DIALOG
Start date: August 20, 2013
Phase: Phase 2
Study type: Interventional

To evaluate the safety, efficacy and pharmacokinetics of nilotinib over time in the Ph+ chronic myelogenous leukemia (CML) in pediatric patients (from 1 to <18 years).