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Female Infertility clinical trials

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NCT ID: NCT06239051 Completed - Female Infertility Clinical Trials

Greening the Humanitas Fertility Center: How to Build a More Sustainable Medical Daily Routine

Green
Start date: September 18, 2023
Phase:
Study type: Observational

The goal of this observational study is to redefine an everyday clinical routine at the Humanitas Fertility center calculating the effects derived from the reduction of inappropriate and avoidable tests, procedures, tools and treatments currently used. Anonymized patients data about clinical procedures are used, taken from the internal database of the Humanitas fertility center

NCT ID: NCT06220227 Completed - Female Infertility Clinical Trials

The Embryologist's Impact on Blastocyst Vitrification and Thawing

Start date: January 1, 2019
Phase:
Study type: Observational

The goal of this monocentric retrospective observational study is to analyse, for the first time in literature, the role of the embryologist who freezes and thaws the embryos. The primary objective of the study is to understand whether the embryologist who freezes and thaws the embryo influences the CPR (clinical pregnancy rate). Secondary objectives, in case of statistically significant influence, are: - Evaluate who influences more the CPR, between the embryologist who freezes the embryos and the embryologist who thaws the embryos. - Evaluate if the embryologist who freezes and thaws the embryo impacts more than the embryologist or the physician who performs the ET. - Evaluate whether the embryologists improve their performances, as their experience increases. - Evaluate, through an external validation test, whether the model used can also be applied at other PMA centres The study will consider all the freezing (vitrifications) and thawing procedures, performed at Humanitas Fertility Center between January 2019 and June 2023. The study will include the transfers of single blastocysts, cryopreserved at Humanitas Fertility Center. On the other hand, the blastocysts transferred from other centres and the donor blastocysts will be excluded from the study, as well as multiple blastocysts transfers and the LP cycles. The embryologist's experience will be assessed in terms of number of previous cryopreservation (vitrification) and thawing procedures. We will include in the study all the embryologists who performed at least 50 freezing and thawing. For the evaluation of the study objectives, data will be gathered using a specific internal web-based database. The final model will be created by analysing the Humanitas Fertility Center dataset and validated using datasets extrapolated from similar population from the San Raffaele Hospital infertility centre

NCT ID: NCT06098495 Recruiting - Female Infertility Clinical Trials

Looking for a Blood Epigenetic Signature to Predict Female Infertility

FIB_CARIPLO
Start date: October 16, 2023
Phase:
Study type: Observational

The present research project aims to study the DNAm mechanisms underlying the reduction of fertility due to the progressive depletion of oocyte quality. Specifically, our project aims to build an epigenetic clock for MGCs by using outcomes that are certainly related to female fertility. The validation of such findings will be carried out on peripheral blood in order to guarantee its non-invasiveness and allow for any clinical transferability. In order to identify a blood epigenetic signature able to predict female infertility, we planned to explore the problem from different points of view by conducting several studies in different settings.

NCT ID: NCT06041204 Recruiting - Female Infertility Clinical Trials

Best Treatment for Women With Both (Polycystic Ovary Syndrome) PCOS and Subclinical Hypothyroidism

Start date: May 6, 2021
Phase: N/A
Study type: Interventional

The goal of this randomized controlled trial is to compare letrozole alone versus letrozole plus levothyroxine for ovulation induction in infertile women with both PCOS and subclinical hypothyroidism. The main questions it aims to answer are: Is letrozole plus levothyroxine superior to letrozole alone in achieving ovulation in these patients? Does combining levothyroxine with letrozole lead to higher pregnancy and live birth rates compared to letrozole alone? Participants will be randomized into two groups: Group 1 will receive letrozole only, starting at 2.5 mg daily from day 3 to 7 of the menstrual cycle. The dose will be increased up to 7.5 mg if no ovulation occurs, for a maximum treatment period of 6 months or until pregnancy is achieved. Group 2 will receive letrozole at the same doses as group 1 plus 25 mcg levothyroxine daily.

NCT ID: NCT06020924 Recruiting - Female Infertility Clinical Trials

The Effects of Uterine Fibroids on Pregnancy in Women

Start date: August 31, 2023
Phase:
Study type: Observational

Female fertility may be affected by uterine fibroids, although this association has not been elucidated. This retrospective cohort study aims to evaluate the impact of fibroids on women fertility.

NCT ID: NCT05858333 Active, not recruiting - Female Infertility Clinical Trials

Extended Culture of Day 3 to Day 5 Frozen Thawed Day 3 Embryos Versus Day 5 Frozen-Thawed Embryos

Start date: April 1, 2022
Phase: N/A
Study type: Interventional

Cryopreservation of embryos and oocytes has become routine in assisted reproduction technology (ART). Live birth rates following frozen embryo transfers have increased significantly. Data show that cryopreservation has significant improved survival rates and cumulative pregnancy rates, as well as the safety of ART . Embryo cryopreservation has become a cornerstone in ART. With improved vitrification techniques. Frozen embryos transfer (FET) shows equal or even higher implantation and pregnancy rates than do fresh embryo transfers ART Previous studies show equal or even superior outcomes regarding pregnancy and live birth rates with frozen versus fresh embryo transfer Cryopreserve all embryos have increased substantially in recent years, and according to the recent trend of a freeze-all strategy. This study aims to answer a clinical question encountered in daily practice regarding at what stage embryos should be frozen.

NCT ID: NCT05608590 Recruiting - Female Infertility Clinical Trials

What is the Best Moment for Performing an HSG in Women With a Unfulfilled Childwish

H2Oil-timing
Start date: August 22, 2019
Phase: Phase 4
Study type: Interventional

The aim of this study is to determine whether direct tubal flushing with oil-based contrast at HSG incorporated in the fertility work-up results in 10% more ongoing pregnancies and a shorter time to pregnancy, which will therefore be effective and cost-effective compared to delayed tubal flushing 6 months after fertility work-up is completed in women at low risk for tubal pathology.

NCT ID: NCT05528835 Completed - Female Infertility Clinical Trials

Caesarean Section and Intracytoplasmic Sperm Injection (ICSI) Outcome

Start date: January 1, 2022
Phase:
Study type: Observational [Patient Registry]

Although Caesarean section (CS) is often a necessary surgical intervention, it may also be associated with an increased risk of short- and long-term sequelae. It was thought that CS may increase the risk of female subfertility or even infertility. In assisted reproductive technology (ART) cycles, the process of implantation is believed to be the most important factor in determining pregnancy outcome. In view of conflicting results on the influence of a previous CS on outcomes of ART, this study will be conducted to investigate the impact of the mode of previous delivery on ICSI outcomes.

NCT ID: NCT05460858 Recruiting - Female Infertility Clinical Trials

NAC Effect on Infertile Women With Endometrioma

Start date: April 13, 2021
Phase: Phase 3
Study type: Interventional

Oxidative stress has been investigated as a key factor in the pathogenesis and progression of endometrioma. High follicular fluid ROS levels and serum can be related to negative IVF/ICSI outcomes in infertile women with endometrioma. Therefore, the use of antioxidants such as N-acetyl cysteine (NAC) may be reduced complications of endometrioma. To study this hypothesis, we designed a double-blind, randomized clinical trial study that aimed to determine the effect of N-acetyl cysteine (NAC) on stress oxidative factors and pregnancy outcomes in IVF/ICSI cycles in endometrioma patients.

NCT ID: NCT05421364 Recruiting - Female Infertility Clinical Trials

Effects of Intrauterine Administration of Autologous PBMC on the Endometrial Cells Populations

Start date: December 9, 2023
Phase: N/A
Study type: Interventional

The behaviour of the endometrium during its receptive phase is highly dependent on the endometrial cell type composition. Each cell type has its role in the endometrial preparation for the invading embryo. Alteration in the immune cells dialogue could be the main reason for unsuccessful implantation in certain patients. Immune cell homeostasis is often improved by intrauterine administration of autologous PBMC. There have been numerous reports on the positive effects of the intrauterine administration of autologous PBMC on the IVF outcomes (embryo implantation and ongoing pregnancy success). However, there is little data on the direct effect of the PBMC administration on the cell composition of the endometrium. This study will focus on the changes in the endometrial cell populations by PBMC treatment that could lead to IVF outcome improvement. The aim of this project is to analyze the effect of intrauterine administration of autologous PBMC on the endometrial cell populations and on the IVF outcome parameters (implantation and ongoing pregnancy success as IVF outcome variables).