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NCT ID: NCT03201757 Completed - Schizophrenia Clinical Trials

Study to Evaluate the Long-term Safety, Tolerability, and Durability of Treatment Effect of ALKS 3831

Start date: June 15, 2017
Phase: Phase 3
Study type: Interventional

This study will evaluate the long-term safety, tolerability, and durability of treatment effect of ALKS 3831 in subjects with schizophrenia, schizophreniform disorder, or bipolar I disorder

NCT ID: NCT03197688 Completed - Clinical trials for Pulmonary Arterial Hypertension

Retrospective Chart Review of First-time Opsumit® (Macitentan) Users in the United States

OrPHeUS
Start date: August 3, 2017
Phase:
Study type: Observational

The Opsumit Users registry (OPUS; NCT02126943) was developed to characterize the safety profile of Opsumit and to describe clinical characteristics and outcomes of patients newly treated with Opsumit in the post-marketing setting. It is expected that the recruitment target of the OPUS registry cannot be achieved within the planned time period (5000 Opsumit new users by October 2018). The OrPHeUS study is designed to supplement the OPUS registry with retrospectively identified first-time Opsumit users in order to achieve the desired sample size.

NCT ID: NCT03188185 Completed - Clinical trials for Major Depressive Disorder

A Study of ALKS 5461 for Treatment Refractory Major Depressive Disorder (MDD)

Start date: June 12, 2017
Phase: Phase 3
Study type: Interventional

This study will evaluate the efficacy, safety, and tolerability of adjunctive ALKS 5461 in adults who have treatment refractory MDD.

NCT ID: NCT03185013 Completed - Cervical Dysplasia Clinical Trials

REVEAL 1 (Evaluation of VGX-3100 and Electroporation for the Treatment of Cervical HSIL)

REVEAL 1
Start date: June 28, 2017
Phase: Phase 3
Study type: Interventional

HPV-301 is a prospective, randomized, double-blind, placebo controlled Phase 3 study to determine the efficacy, safety, and tolerability of VGX-3100 administered by intramuscular (IM) injection followed by electroporation (EP) delivered with CELLECTRA™ 5PSP in adult women with histologically confirmed cervical high grade squamous intraepithelial lesion (HSIL) (cervical intraepithelial neoplasia grade 2 [CIN2] or grade 3 [CIN3]) associated with human papillomavirus (HPV) 16 and/or HPV-18.

NCT ID: NCT03179631 Completed - Clinical trials for Nervous System Diseases

Long-Term Outcomes of Ataluren in Duchenne Muscular Dystrophy

Start date: July 6, 2017
Phase: Phase 3
Study type: Interventional

This study is a long-term study of ataluren in participants with nonsense mutation Duchenne muscular dystrophy.

NCT ID: NCT03178942 Completed - Scabies Clinical Trials

Multiple-Site Study to Evaluate the Therapeutic Equivalence of Permethrin Cream, 5% in the Treatment of Scabies

Start date: June 1, 2017
Phase: Phase 3
Study type: Interventional

Study to Evaluate the Therapeutic Equivalence of Permethrin Cream 5%in the Treatment of Scabies.

NCT ID: NCT03160547 Completed - Critical Illness Clinical Trials

The Effect of Higher Protein Dosing in Critically Ill Patients

EFFORT
Start date: November 21, 2017
Phase: N/A
Study type: Interventional

The investigator will investigate the effects of higher protein/amino acid dosing (≥2.2 g/kg/d) vs usual protein/amino acid dosing (≤1.2 g/kg/d) on clinical outcomes in nutritionally high risk ill patients.

NCT ID: NCT03158233 Completed - Zika Virus Disease Clinical Trials

Zika Case Definition and Surveillance Study

Start date: April 29, 2017
Phase:
Study type: Observational

This prospective, surveillance study will assess the operational Zika virus definition for use in future Zika purified inactivated virus (ZIKV) vaccine efficacy trials in order to identify Zika virus disease (ZVD) cases among the study cohort.

NCT ID: NCT03134755 Completed - Asthma in Children Clinical Trials

Stress and Treatment Response in Puerto Rican Children With Asthma

STAR
Start date: May 15, 2018
Phase:
Study type: Observational

This study aims to first determine whether high child stress leads to reduced response to common treatmenIs for asthma (inhaled corticosteroids and short-acting bronchodilators), and then to identify DNA methylation differences leading to stress-induced treatment resistance among children with asthma.

NCT ID: NCT03131687 Completed - Clinical trials for Type 2 Diabetes Mellitus

A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes Mellitus

Start date: May 24, 2017
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the efficacy of the study drug tirzepatide in participants with type 2 diabetes mellitus.